CORDIS
EU research results

CORDIS

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European-Latin American network for the assessment of biomarkers to predict and diagnose hepatobiliary malignancies and characterization of risk factors for cancer development

Project information

Grant agreement ID: 825510

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 3 503 475

  • EU contribution

    € 3 283 475

Coordinated by:

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

Objective

Hepatobiliary malignancies represent a major cause of mortality globally and are uniquely aggressive in Latin America. The most common tumors are: hepatocellular carcinoma (HCC) affecting young individuals in Latin America and being the second most common cause of cancer-related death worldwide; cholangiocarcinoma (CCA) with minimal survival upon diagnosis and largely understudied in the region; gallbladder cancer (GBC) being a rare tumor worldwide but representing the second most common cause of cancer-related death in women in Chile. Key factors related to the excessive mortality of these tumors are the lack of reliable screening methods and the complexity of diagnosis, which requires advanced imaging technology and difficult-to-access tissue. These barriers are amplified by poor accessibility present in resource-limited regions, all of which leads to tumors being diagnosed at advanced stages in which curative therapy is not an option.
To overcome these barriers, we propose to: A) validate immune-related markers in serum to predict HCC in South America and evaluate factors associated to early HCC development; B) define the utility of extracellular vesicles in serum as biomarkers for diagnosis of CCA and determine genetic and infectious factors that increase risk for this cancer; and C) identify biomarkers for GBC detection and evaluate novel immune factors that affect the geographical impact of this tumor.
This project advances the field by focusing on a unique approach to screen and diagnose tumors based on serum detection of biomarkers before a tumor is visible on imaging, allowing for early tumor detection in a cost effective manner that will lead to implementation of curative therapies. In addition, this project addresses modifiable risk factors for hepatobiliary tumors that could be targeted for prevention. This project will result in novel tools that are easily accessible and will dramatically reduce the burden of cancer-related mortality in Latin America.
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Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Address

Dr Molewaterplein 40
3015 Gd Rotterdam

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 386 725

Participants (10)

ASOCIACION INSTITUTO BIODONOSTIA

Spain

EU Contribution

€ 550 000

UNIVERSIDAD SAN FRANCISCO DE QUITO

Ecuador

EU Contribution

€ 172 750

HOSPIAL PRIVADO CENTRO MEDICO DE CORDOBA SA

Argentina

EU Contribution

€ 301 250

CENTRO DE ENFERMEDADES HEPATICAS Y DIGESTIVAS SAS

Colombia

EU Contribution

€ 117 750

FUNDACAO UNIVERSIDADE FEDERAL DE CIENCIAS DA SAUDE DE PORTO ALEGRE

Brazil

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

EU Contribution

€ 430 000

THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Canada

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 85 000

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

EU Contribution

€ 145 000

SENSU HOLDING BV

Netherlands

EU Contribution

€ 95 000

Project information

Grant agreement ID: 825510

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 3 503 475

  • EU contribution

    € 3 283 475

Coordinated by:

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands