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European-Latin American network for the assessment of biomarkers to predict and diagnose hepatobiliary malignancies and characterization of risk factors for cancer development

Objective

Hepatobiliary malignancies represent a major cause of mortality globally and are uniquely aggressive in Latin America. The most common tumors are: hepatocellular carcinoma (HCC) affecting young individuals in Latin America and being the second most common cause of cancer-related death worldwide; cholangiocarcinoma (CCA) with minimal survival upon diagnosis and largely understudied in the region; gallbladder cancer (GBC) being a rare tumor worldwide but representing the second most common cause of cancer-related death in women in Chile. Key factors related to the excessive mortality of these tumors are the lack of reliable screening methods and the complexity of diagnosis, which requires advanced imaging technology and difficult-to-access tissue. These barriers are amplified by poor accessibility present in resource-limited regions, all of which leads to tumors being diagnosed at advanced stages in which curative therapy is not an option.
To overcome these barriers, we propose to: A) validate immune-related markers in serum to predict HCC in South America and evaluate factors associated to early HCC development; B) define the utility of extracellular vesicles in serum as biomarkers for diagnosis of CCA and determine genetic and infectious factors that increase risk for this cancer; and C) identify biomarkers for GBC detection and evaluate novel immune factors that affect the geographical impact of this tumor.
This project advances the field by focusing on a unique approach to screen and diagnose tumors based on serum detection of biomarkers before a tumor is visible on imaging, allowing for early tumor detection in a cost effective manner that will lead to implementation of curative therapies. In addition, this project addresses modifiable risk factors for hepatobiliary tumors that could be targeted for prevention. This project will result in novel tools that are easily accessible and will dramatically reduce the burden of cancer-related mortality in Latin America.

Field of science

  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 346 475

Participants (12)

ASOCIACION INSTITUTO BIODONOSTIA
Spain
EU contribution
€ 550 000
Address
Paseo Dr. Beguiristain S/n
20014 Donostia-san Sebastian
Activity type
Research Organisations
UNIVERSIDAD SAN FRANCISCO DE QUITO
Ecuador
EU contribution
€ 166 500
Address
Calle Diego De Robles S N Y Pampite Esq
1712145 Quito
Activity type
Other
HOSPIAL PRIVADO CENTRO MEDICO DE CORDOBA SA
Argentina
EU contribution
€ 295 000
Address
Avenida Naciones Unidas 346
5016 Cordoba
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRO DE ENFERMEDADES HEPATICAS Y DIGESTIVAS SAS
Colombia
EU contribution
€ 117 750
Address
Calle 127 No 19 A 28
110121 Bogota
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACAO UNIVERSIDADE FEDERAL DE CIENCIAS DA SAUDE DE PORTO ALEGRE
Brazil
EU contribution
€ 0
Address
Rua Sarmento Leite 245
90050 170 Porto Alegre
Activity type
Higher or Secondary Education Establishments
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Chile
EU contribution
€ 418 250
Address
Avenida Libertador Bernardo O'higgins 340
8331150 Santiago
Activity type
Higher or Secondary Education Establishments
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Canada
EU contribution
€ 0
Address
Kings College Circle 27
M5S 1A1 Toronto
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 35 000
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 145 000
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
SENSU HOLDING BV
Netherlands
EU contribution
€ 95 000
Address
Emmaplein 1
9711 AP Groningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSIDAD SAN MARTIN DE PORRES ASOCIACION
Peru
EU contribution
€ 62 500
Address
Av. Las Calandrias, Santa Anita
43 Lima
Activity type
Higher or Secondary Education Establishments
THE CHRISTIE NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 52 000
Address
Wilmslow Road 1
M20 4BX Manchester
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)