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Super-sensitive detection of Alzheimer’s disease biomarkers in plasma by an innovative droplet split-and-stack approach

Project description

Early diagnosis of Alzheimer’s disease

Clinical practice employs immunoassay methods for the detection of diagnostic biomarkers in body fluids. However, in cases where the concentration of biomarkers falls below the limit of detection (LOD), these techniques fail to provide results. Alzheimer’s disease (AD) represents an example where low biomarker concentration in the blood makes diagnosis impossible. The EU-funded SensApp project is developing a super-sensitive technique to determine the concentration of AD biomarkers in plasma from peripheral blood samples for early non-invasive diagnosis in routine clinical practice. The so-called droplet split-and-stack technology will stack the biomarker molecules in sub-microlitre volumes on a solid support before immunodetection, avoiding diffusion and improving the LOD with an innovative integrated optical system detecting the fluorescence signal directly on the reaction support.

Call for proposal

H2020-FETOPEN-2018-2020

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Sub call

H2020-FETOPEN-2018-2019-2020-01

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Net EU contribution
€ 831 562,50
Address
Piazzale Aldo Moro 7
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Other funding
€ 0,00

Participants (5)

VRIJE UNIVERSITEIT BRUSSEL
Belgium
Net EU contribution
€ 654 200,00
Address
Pleinlaan 2
1050 Brussel

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
IRCCS CENTRO NEUROLESI BONINO PULEJO
Italy
Net EU contribution
€ 124 375,00
Address
Ctr Casazza Via Palermo Ss 113
98124 Messina

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Region
Isole Sicilia Messina
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITAT LINZ
Austria
Net EU contribution
€ 416 197,50
Address
Altenberger Strasse 69
4040 Linz

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Region
Westösterreich Oberösterreich Linz-Wels
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
Finland
Net EU contribution
€ 762 477,50
Address
Tekniikantie 21
02150 Espoo

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Research Organisations
Other funding
€ 0,00
GINOLIS OY
Finland
Net EU contribution
€ 498 750,00
Address
Automaatiotie 1
90460 Oulunsalo

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00