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The use of proportional palliative sedation for the relief of refractory symptoms: an international multicenter study

The use of proportional palliative sedation for the relief of refractory symptoms: an international multicenter study

Objective

Due to the rise in cancer and multiple chronic disease, the number of patients with refractory symptoms, ie severe symptoms where conventional treatment options fail, is likely to increase. In such cases palliative sedation (PS) can be indicated which involves the intentional lowering of consciousness at the end of life. However PS is too often restricted to continuous deep sedation and confused with hastening of death. This proposal offers a modified concept, namely proportional PS, with titration of sedatives up to the point of symptom control to improve patient comfort. Firstly, the project will offer a review about state-of-the-art refractory symptom management and a country survey. Secondly, an observational multicenter study will be performed in five countries to study the effect of proportional PS at patient comfort and symptom relief. Thirdly, a multiple case study of 50 cases will investigate caregivers and family experiences. Fourthly, moral case deliberation will be studied as a tool to improve multidisciplinary decision making for the treatment of refractory symptoms/PS in 16 clinical centers in 8 countries, including the effect on caregiver emotional distress. Fifthly, a Cost Consequence Analysis will be provided to feed a policy workshop and recommendations for the further development of palliative sedation in Europe. Sixthly, a revision of the 2009 EAPC framework for PS will be undertaken, using a Delphi procedure. Finally, a free online education programme will be delivered together with an abook and a closing congress and webinar to support dissemination. The project consortium consists of experts in the field of palliative care and PS from 8 North-Western, Southern, and Central-Eastern European countries. Renowned advisory board members are involved among which the European Cancer Patient Coalition to foster the patient perspective. A dedicated European taksforce for PS is foreseen as a follow up after the project's finalization.
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Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

Geert Grooteplein Noord 9
6525 Ez Nijmegen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 783 442

Participants (9)

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UNIVERSIDAD DE NAVARRA

Spain

EU Contribution

€ 607 125

PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS

Hungary

EU Contribution

€ 279 250

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 600 000

Hospice Casa Sperantei

Romania

EU Contribution

€ 200 125

UNIVERSITAETSKLINIKUM BONN

Germany

EU Contribution

€ 584 000

UNIVERSITY OF LANCASTER

United Kingdom

EU Contribution

€ 502 016,25

EUROPEAN ASSOCIATION OF PALLIATIVE CARE

Belgium

EU Contribution

€ 140 000

LA MADDALENA SPA

Italy

EU Contribution

€ 321 250

EUROPEAN CANCER PATIENT COALITION

Belgium

EU Contribution

€ 16 312

Project information

Grant agreement ID: 825700

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 4 033 520,75

  • EU contribution

    € 4 033 520,25

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands