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Training innovative future leaders in research and development of materials and implants for the spine

Training innovative future leaders in research and development of materials and implants for the spine

Objective

This proposal aims to develop Early-Stage Researchers into innovative European leaders in biomedical engineering, with a focus on spinal devices. Synergies will be drawn from the involved high-quality research centres in the interdisciplinary fields of materials science, mechanical engineering and biology, which will permit acquiring expertise in the development and preclinical testing of such devices, with a focus on meeting current and future societal challenges related to implant longevity and biocompatibility. The training programme has been put together in close collaboration with the relevant industry, SME’s as well as larger enterprise, ensuring adequate exposure to these environments, through e.g. secondments, as well as a knowledge base permitting a seamless transfer into industry and fostering innovation. An expert in industrial engineering and management will undertake co-ordination of the innovation-related training as well as consist of an independent career coach to the young researchers.
The growing elderly, more active population puts higher demands on implants, which need to last longer and provide an adequate biological response throughout their lifetime. Current solutions for the spine suffer from a variety of issues, such as implant subsidence as well as potentially detrimental metal ion release and wear products. The current proposal aims to provide alternatives to these, by developing novel materials and implants for the spine, which provide i) non-detrimental wear products and reduced metal ion release and/or ii) enhanced osseointegration. Since many implant failures can be linked to inadequate loading, considerable effort will be spent on developing methods that simulate more closely adverse and individual biomechanical environments, as well as adapting implant designs to these situations. Adequate biological response will be evaluated through in vitro and in vivo models, closing the circle of the pre-clinical testing value chain.
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Coordinator

UPPSALA UNIVERSITET

Address

Von Kraemers Alle 4
751 05 Uppsala

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 127 931,84

Participants (5)

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EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 843 829,92

UNIVERSITY OF LEEDS

United Kingdom

EU Contribution

€ 1 212 690,24

IHI IONBOND AG

Switzerland

EU Contribution

€ 281 276,64

KEY ENGINEERING SOLUTIONS LIMITED

United Kingdom

EU Contribution

€ 303 172,56

CERAMTEC GMBH

Germany

EU Contribution

€ 505 576,80

Partners (3)

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OSSDSIGN AB

THE LEEDS TEACHING HOSPITALS NATIONAL HEALTH SERVICE TRUST

Amedica Corporation

Project information

Grant agreement ID: 812765

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 4 274 478

  • EU contribution

    € 4 274 478

Coordinated by:

UPPSALA UNIVERSITET

Sweden