Harnessing non-linear inverse scattering for unprecedented resolution imaging at the nanoscale
Optical nanoscopy without photobleaching and photochemical toxicity of fluorescence labels and with 3D morphological resolution of less than 50 nm represents a new horizon in live-cell imaging. The goal of the EU-funded 3D-nanoMorph project is to achieve isotropic 3D resolution of less than 50 nm by performing non-linear inverse scattering between sub-cellular structures, such as organelles. This innovative project approach devises complementary roles of the light measurement system and computational nanoscopy algorithm. The pilot study will involve organelle autophagy in live cancer cells over an extended period with high spatio-temporal resolution. Successful 3D mapping of this nanoscale process will provide proof of applicability of the 3D-nanoMorph nanoscopy for a broad spectrum of applications.
Fields of science
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Funding SchemeERC-STG - Starting Grant
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