CORDIS
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CORDIS

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A STEP FORWARD TO SPINAL CORD INJURY REPAIR USING INNOVATIVE STIMULATED NANOENGINEERED SCAFFOLDS

A STEP FORWARD TO SPINAL CORD INJURY REPAIR USING INNOVATIVE STIMULATED NANOENGINEERED SCAFFOLDS

Objective

Spinal cord injury (SCI) is a devastating pathology with dramatic lifetime consequences affecting thousands of people worldwide. Therefore, and considering the very limited regeneration ability of the central nervous system, in this project we propose to develop a neural tissue engineered scaffold capable of not only combining fibrous and porous topographic cues in order to mimic the morphology of the native spinal cord, but also potentiating the properties of graphene related materials (GRM) supported in a protein-rich decellularized matrix (adECM). In fact, the suggested 3D microenvironment should present electrical, chemical, mechanical and topographic features able to preserve neural cell survival and enhance neural progenitor cell differentiation towards neuronal and glial cells. Progress in this sense will contribute to a better understanding of the key factors controlling repair in damaged neural tissues and, consequently, bring insights into new therapeutic approaches for spinal cord recovery.
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Coordinator

UNIVERSIDADE DE AVEIRO

Address

Campus UniversitÁRio De Santiago
3810-193 Aveiro

Portugal

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 075 260

Participants (6)

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FUNDACION TECNALIA RESEARCH & INNOVATION

Spain

EU Contribution

€ 727 162,50

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

EU Contribution

€ 251 250

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 500 000

FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS

Greece

EU Contribution

€ 338 375

GRAPHENEST SA

Portugal

EU Contribution

€ 208 750

Stemmatters, Biotecnologia e Medicina Regenerativa SA

Portugal

EU Contribution

€ 403 125

Project information

Grant agreement ID: 829060

Status

Ongoing project

  • Start date

    1 April 2019

  • End date

    31 March 2023

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 3 518 962,50

  • EU contribution

    € 3 503 922,50

Coordinated by:

UNIVERSIDADE DE AVEIRO

Portugal