CORDIS
EU research results

CORDIS

English EN
Photonic and nAnomeTric High-sensitivity biO-Sensing

Photonic and nAnomeTric High-sensitivity biO-Sensing

Objective

We plan to develop a radically new technology for the sensing of bio-systems and in-vivo diagnostics of biomedical conditions using hitherto unexploited tools of unconventional complex-system dynamical control and information sampling/processing. They will be founded on groundbreaking concepts and challenging experiments, with the following aims: (a) Magnetic-resonance imaging (MRI) and optically-detected magnetic-resonance (ODMR) sensing will be dramatically improved by orders of magnitude through highly selective cooling/suppression of thermal noisy background in-vivo with unprecedented spectral and spatial (subnano- or submicron-) resolution. It will be based on so far unemployed (but conceptually proven) stochastic (anti-) Zeno effects and collective-spin cooling pioneered by the partners of this very interdisciplinary consortium. (b) Development of novel probing configurations and protocols: NMR intra-molecule/intra-tissue sensing and intra-cell NV-center thermometry based on dynamical control being aimed at unravelling of hitherto invisible biochemical activity features masked by inhomogeneous broadening. (c) Advanced sensing-data processing, including high-order correlation spectroscopy – innovative strategies that seek to exploit dynamically controlled/modified noise in bio-systems as a source of previously untapped information on physiological (temporal) processes and anatomical (structural) detail. This information will be obtained by treating bio-systems as complex, noisy “environments” through novel probing/estimation procedures and compressed (sparse) imagery of the spectrally and spatially structured “environment”, but reducing drastically their complexity by dynamically controlling the relevant information encoded by key noise parameters. The overarching goal will be to substantially enrich the spatial and spectral information content and robustness of diverse medical diagnostic procedures and thereby minimize the exposure time/irradiation dosage.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITA DEGLI STUDI DI FIRENZE

Address

Piazza San Marco 4
50121 Florence

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 536 250

Participants (4)

Sort alphabetically

Sort by EU Contribution

Expand all

ISTITUTO NAZIONALE DI RICERCA METROLOGICA

Italy

EU Contribution

€ 506 250

WEIZMANN INSTITUTE OF SCIENCE

Israel

EU Contribution

€ 500 000

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

EU Contribution

€ 512 500

TECHNISCHE UNIVERSITAT DORTMUND

Germany

EU Contribution

€ 512 500

Project information

Grant agreement ID: 828946

Status

Ongoing project

  • Start date

    1 April 2019

  • End date

    31 March 2024

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 2 567 500

  • EU contribution

    € 2 567 500

Coordinated by:

UNIVERSITA DEGLI STUDI DI FIRENZE

Italy