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Photonic and nAnomeTric High-sensitivity biO-Sensing

Project description

Improved in vivo diagnostics

Medical diagnostic procedures employ a variety of different technologies, including magnetic resonance imaging (MRI). To minimise the exposure time and radiation risk of such procedures, scientists of the EU-funded PATHOS project are working to optimise the spectral and spatial resolution of MRI. Given that biological systems are complex and noisy environments, researchers are developing novel NMR-based probing configurations and protocols for enhanced intra-molecule and intra-tissue sensing. These novel tools will help unveil biochemical features otherwise masked by tissue heterogeneity, while advanced data processing will control the noise generated by complex biological systems.


We plan to develop a radically new technology for the sensing of bio-systems and in-vivo diagnostics of biomedical conditions using hitherto unexploited tools of unconventional complex-system dynamical control and information sampling/processing. They will be founded on groundbreaking concepts and challenging experiments, with the following aims: (a) Magnetic-resonance imaging (MRI) and optically-detected magnetic-resonance (ODMR) sensing will be dramatically improved by orders of magnitude through highly selective cooling/suppression of thermal noisy background in-vivo with unprecedented spectral and spatial (subnano- or submicron-) resolution. It will be based on so far unemployed (but conceptually proven) stochastic (anti-) Zeno effects and collective-spin cooling pioneered by the partners of this very interdisciplinary consortium. (b) Development of novel probing configurations and protocols: NMR intra-molecule/intra-tissue sensing and intra-cell NV-center thermometry based on dynamical control being aimed at unravelling of hitherto invisible biochemical activity features masked by inhomogeneous broadening. (c) Advanced sensing-data processing, including high-order correlation spectroscopy – innovative strategies that seek to exploit dynamically controlled/modified noise in bio-systems as a source of previously untapped information on physiological (temporal) processes and anatomical (structural) detail. This information will be obtained by treating bio-systems as complex, noisy “environments” through novel probing/estimation procedures and compressed (sparse) imagery of the spectrally and spatially structured “environment”, but reducing drastically their complexity by dynamically controlling the relevant information encoded by key noise parameters. The overarching goal will be to substantially enrich the spatial and spectral information content and robustness of diverse medical diagnostic procedures and thereby minimize the exposure time/irradiation dosage.

Call for proposal


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Net EU contribution
€ 536 250,00
Piazza san marco 4
50121 Florence

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Centro (IT) Toscana Firenze
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (4)