Sources of phenotypic variation in complex vertebrates
The goal of the EU-funded IndiGene project is the in-depth study and characterisation of the sources of variation resulting in phenotype variability in complex vertebrates. The project will characterise the genetic and environmental sources of variation and individual stochastic variation occurring even in fixed genetic and environmental conditions. Researchers selected the medaka fish (Japanese rice fish) as a model, and inbred and performed whole-genome sequencing of a panel of 111 diverse individual medaka from a single location. Now they plan to study the phenotypes of these fish using a high-replication structure, ranging from organism to molecular phenotypes. The data will be analysed using state-of-the-art methods to partition variation between genetic, environmental and stochastic components and their interactions.
Call for proposal
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