CORDIS
EU research results

CORDIS

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Genetics of Individuality

Project information

Grant agreement ID: 810172

Status

Ongoing project

  • Start date

    1 February 2019

  • End date

    31 January 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 6 272 613

  • EU contribution

    € 6 272 613

Hosted by:

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

Objective

We propose to thoroughly investigate and characterise the sources of variation that results in varying phenotypes in a complex vertebrate. As well as characterising the genetic and environmental sources of variation, we will also investigate individual stochastic variation present even in fixed settings (both genetically and environmentally). To achieve this we will exploit the unique properties of Medaka fish, which can be fully inbred from the wild. We have already inbred and performed whole genome sequencing of a panel of 111 diverse Medaka fish from a single location; we propose to phenotype these fish in depth with high replication structure, ranging from organismal to molecular phenotypes. We will also phenotype entirely wild fish from the same source population as the panel with a subset of the phenotypes. We will analyse the data using state of the art methods to partition variation between genetic, environmental and stochastic components, and their interactions. We will integrate across both the different levels of phenotypic information across the cardiovascular system, and also across vertebrate phenotypes, in particular the extensive human phenotypes. By using genetic crosses and CRISPR-Cas9 techniques we will definitively prove specific interactions. We will host a “Research Hotel” for other phenotyping schemes to be applied to this panel, in particular from the Zebrafish community. This comprehensive and carefully replicated study will allow us to understand the opportunities and limitations of genetic stratification and personalised medicine in humans.

Host institution

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Address

Meyerhofstrasse 1
69117 Heidelberg

Germany

Activity type

Research Organisations

EU Contribution

€ 1 668 988

Beneficiaries (3)

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 1 668 988

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Germany

EU Contribution

€ 4 003 625

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Germany

EU Contribution

€ 600 000

Project information

Grant agreement ID: 810172

Status

Ongoing project

  • Start date

    1 February 2019

  • End date

    31 January 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 6 272 613

  • EU contribution

    € 6 272 613

Hosted by:

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany