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Project on Exercise for Fatigue Eradication in Advanced Breast cancer to improve quality of life

Objective

Despite the tremendous improvement in early diagnosis and treatment of breast cancer, a large proportion (up to 40%) of patients with breast cancer will eventually develop metastases. Patients with metastatic breast cancer (MBC) have a median overall survival of 2-3 years, and a relative 5-year survival of 34%. Current advances in therapy have extended the life of those patients with MBC, however these patients still suffer (for longer periods) from deleterious side-effects (either related to the disease itself or to the treatment) such as fatigue, pain, nausea and vomiting, insomnia, dyspnoea, emotional, social and cognitive dysfunction. Among all these side-effects, fatigue is the most common and distressing treatment-related side-effect, as up to 90% of patients with MBC experience fatigue over the course of treatment. All these symptoms negatively affect patients’ QoL and thus an urgent solution is needed to help those with advanced breast cancer to “live well” for as long as possible.
PREFERABLE’s vision is to improve the standard of care in MBC by improving the quality, effectiveness and cost-effectiveness for patients in a palliative setting using a non-pharmacological intervention combining supervised and unsupervised app-based exercise. Based on the results from a multinational randomised controlled phase 3 clinical trial (EFFECT trial; (cost)- effectiveness study), the different perspectives of patients with MBC on exercising (PERSPECTIVE study), and through mapping the differences in the European healthcare systems, the PREFERABLE project will generate solid and conclusive evidence of the beneficial effect of exercise on cancer-related side effects and patients’ quality of life in the palliative setting. By this, PREFERABLE will contribute towards reshaping medical practice and improving clinical guidelines and recommendations.
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Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Address

Heidelberglaan 100
3584 Cx Utrecht

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 025 436

Participants (11)

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JULIUS CLINICAL RESEARCH BV

Netherlands

EU Contribution

€ 724 040

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Netherlands

EU Contribution

€ 381 770

Heidelberg University Hospital

Germany

EU Contribution

€ 77 741

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

EU Contribution

€ 235 025

DEUTSCHE SPORTHOCHSCHULE KOLN

Germany

EU Contribution

€ 242 025

NUROGAMES GMBH

Germany

EU Contribution

€ 336 625

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 406 035

GDANSKI UNIWERSYTET MEDYCZNY

Poland

EU Contribution

€ 260 850

FUNDACION ONKOLOGIKOA FUNDAZIOA

Spain

EU Contribution

€ 262 550

EUROPA DONNA THE EUROPEAN BREAST CANCER COALITION

Italy

EU Contribution

€ 31 250

AUSTRALIAN CATHOLIC UNIVERSITY LIMITED

Australia

Project information

Grant agreement ID: 825677

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 4 121 130

  • EU contribution

    € 3 983 347

Coordinated by:

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands