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Fast, Flexible, and Convenient: a simple insert system for the in situ NMR analysis of very fast reactions on a modern open-access FT NMR spectrometer

Fast, Flexible, and Convenient: a simple insert system for the in situ NMR analysis of very fast reactions on a modern open-access FT NMR spectrometer

Objective

The project will involve further design and development of our methodology, developed under the ERC Advanced grant 'arylator', for variable ratio in situ stopped flow NMR. The methodology has recently been published and its power amply demonstrated in the deconvolution of the mechanism for CF3 transfer from Ruppert's reagent to electrophiles. The equipment that will developed and demonstrated under tenure of a proof of concept grant will reduce the dead time from 0.2 seconds to a matter of milliseconds whilst retaining the flexibility of our current system. Thus a standard walk-up NMR spectrometer can thus be used ad hoc for the analysis of very fast homogeneous reactions. This will be transformative for the mechanistic analysis of reactions, including catalysed and enzymatic processes, and will significantly enhance the commercial potential of the stopped flow NMR system.
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Host institution

THE UNIVERSITY OF EDINBURGH

Address

Old College, South Bridge
Eh8 9yl Edinburgh

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 147 076

Beneficiaries (1)

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THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 147 076

Project information

Grant agreement ID: 838616

Status

Ongoing project

  • Start date

    1 March 2019

  • End date

    31 August 2020

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 147 076

  • EU contribution

    € 147 076

Hosted by:

THE UNIVERSITY OF EDINBURGH

United Kingdom