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individualizedPaediatricCure: Cloud-based virtual-patient models for precision paediatric oncology

Project information

Grant agreement ID: 826121

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.3.1.5.3.

  • Overall budget:

    € 15 066 525

  • EU contribution

    € 14 748 400

Coordinated by:

TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH

Austria

Objective

Effective personalized medicine for paediatric cancers must address a multitude of challenges, including domain-specific challenges. To overcome these challenges, we propose a comprehensive computational effort to combine knowledge-base, machine-learning, and mechanistic models to predict optimal standard and experimental therapies for each child. Our approach is based on virtual patient models–in-silico avatars whose analysis can inform personalized diagnostics and recommend treatments. Our platform will also allow care givers to query models and infer benefits and drawbacks for specific treatment combinations for each child. To construct these models, we will combine state-of-the-art computational methods and data from molecular assays, and clinical and preclinical studies. We will test their predictions prospectively on data from clinical trials and test therapies in pre-clinical settings. We will focus on a select panel of paediatric tumours including both high-incidence and high-risk tumour types. To accomplish our goals, we have assembled an interdisciplinary team consisting of basic, translational, and clinical researchers—all amongst the leaders in their respective fields—and established strong relationships with European Centres of Excellence, patient organizations, and clinical trials focus on personalized medicine for our proposed case studies. We will produce, assemble, standardize, and harmonize accessible high-quality multi-disciplinary data and leverage the potential of Big Data and HPC for the personalized treatments of European citizens. We will make our models and data available through a cloud-based platform, whose exploitation will be maximised through a collaboration with the European Open Science Cloud initiative. In summary, iPC will address the critical need for personalized medicine for children with cancer, contribute to the digitalization of clinical workflows, and enable the Digital Single Market of the EU data infrastructure.

Coordinator

TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH

Address

Burgplatz 3a
9500 Villach

Austria

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 513 004,90

Participants (20)

IBM RESEARCH GMBH

Switzerland

EU Contribution

€ 2 020 506,73

BAYLOR COLLEGE OF MEDICINE

United States

EU Contribution

€ 1 104 991,11

INSTITUT CURIE

France

EU Contribution

€ 1 381 550,34

TECHNISCHE UNIVERSITAT DARMSTADT

Germany

EU Contribution

€ 720 673,46

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Italy

EU Contribution

€ 482 857,45

UNIVERSITEIT GENT

Belgium

EU Contribution

€ 668 974,33

BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION

Spain

EU Contribution

€ 980 414,89

XLAB RAZVOJ PROGRAMSKE OPREME IN SVETOVANJE DOO

Slovenia

EU Contribution

€ 369 243,94

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV

Netherlands

EU Contribution

€ 629 109,94

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 769 881,06

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU Contribution

€ 437 262,55

UNIVERSITATSKLINIKUM HEIDELBERG

Germany

EU Contribution

€ 452 750

INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL

Spain

EU Contribution

€ 397 398,16

ALACRIS THERANOSTICS GMBH

Germany

EU Contribution

€ 861 444,60

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 1 451 213,36

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

EU Contribution

€ 531 691,33

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 414 838,83

THE CHILDREN'S HOSPITAL OF PHILADELPHIA NON PROFIT ORG

United States

EU Contribution

€ 175 652,48

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 384 940,54

CHILDREN'S MEDICAL RESEARCH INSTITUTE

Australia

Project information

Grant agreement ID: 826121

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.3.1.5.3.

  • Overall budget:

    € 15 066 525

  • EU contribution

    € 14 748 400

Coordinated by:

TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH

Austria