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Vaccines and Infectious Diseases in the Ageing PopuLation

Vaccines and Infectious Diseases in the Ageing PopuLation

Objective

Today’s major challenge is to improve efficacy of vaccines to protect the growing ageing population against infectious diseases (ID). The VITAL project aims to address this challenge by assessing the ID burden and mechanisms of immunosenescence to provide evidence-based knowledge on vaccination strategies to establish healthy ageing. Links with existing projects containing data sources combined with novel data acquired through our extensive network of dataregistries across Europe will result in a database of epidemiology, risk factors and burden of disease of both vaccine-preventable (VP) and potential vaccine-preventable ID. Crucial knowledge on factors that hamper immune responsiveness and in-depth analyses of immune compartments involved in inducing effective immune responses to different vaccines in the ageing host will be gathered. We will identify novel predictive, potentially universal immune profiles of vaccine responses using novel technologies, unique experimental models and (infection) cohorts of elderly subjects in which (bio)markers of frailty have already been identified. Novel strategies to address the problem of immunosenescence will be tested, in particular whether vaccination of middle-aged individuals can maintain proper memory immune responses in the elderly, to improve memory immunity before reaching old age. Using data on epidemiology of VPID and immune responsiveness, novel agent-based models will be developed to build a user-friendly tool to be used by health care professionals for optimal implementation of vaccination strategies for older people and to develop dissemination protocols for the obtained knowledge for the health care field. Finally, we will deliver a framework that forms the basis for designing, implementing and regularly updating vaccination schemes for the ageing population. Thereby, VITAL will initiate an important impetus to a more targeted immunization program for the elderly in Europe that will enhance healthy aging.
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Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Address

Heidelberglaan 100
3584 Cx Utrecht

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 781 750

Participants (23)

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RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

EU Contribution

€ 1 977 721,25

P95 CVBA

Belgium

EU Contribution

€ 186 375

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 363 750

FOLKEHELSEINSTITUTTET

Norway

EU Contribution

€ 348 472,50

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 230 000

STATENS SERUM INSTITUT

Denmark

EU Contribution

€ 206 936

UNIVERSITAET INNSBRUCK

Austria

EU Contribution

€ 263 750

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 12 500

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 12 500

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 12 500

ISTITUTO SUPERIORE DI SANITA

Italy

EU Contribution

€ 90 602,50

FUNDACION PARA EL FOMENTO DE LA INVESTIGACION SANITARIA Y BIOMEDICA DE LA COMUNITAT VALENCIANA

Spain

EU Contribution

€ 291 423,75

SYREON KUTATO INTEZET KORLATOLT FELELOSSEGU TARSASAG

Hungary

EU Contribution

€ 230 976,25

UNIVERSITA DEGLI STUDI DI FERRARA

Italy

EU Contribution

€ 230 625

UNIVERSITE JEAN MONNET SAINT-ETIENNE

France

EU Contribution

€ 200 000

MIHAJLOVIC JOVAN

Serbia

EU Contribution

€ 60 000

GLAXOSMITHKLINE BIOLOGICALS SA

Belgium

PFIZER LIMITED

United Kingdom

SANOFI PASTEUR SA

France

MERCK SHARP & DOHME CORP

United States

JANSSEN VACCINES & PREVENTION BV

Netherlands

BIOMERIEUX SA

France

FEDERATION EUROPEENNE D'ASSOCIATIONS ET D'INDUSTRIES PHARMACEUTIQUES

Belgium

Project information

Grant agreement ID: 806776

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.7.

  • Overall budget:

    € 12 427 217,59

  • EU contribution

    € 5 499 882,25

Coordinated by:

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands