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Order and Disorder at the Surface of Biological Membranes.

Publikacje

Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

Autorzy: Daniel K Weber, U Venkateswara Reddy, Songlin Wang, Erik K Larsen, Tata Gopinath, Martin B Gustavsson, Razvan L Cornea, David D Thomas, Alfonso De Simone, Gianluigi Veglia
Opublikowane w: eLife, Numer 10, 2021, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.66226

Backbone NMR assignments of the C-terminal domain of the human prion protein and its disease‐associated T183A variant

Autorzy: Mario Sanz-Hernández, Alfonso De Simone
Opublikowane w: Biomolecular NMR assignments, 2021, ISSN 1874-2718
Wydawca: Springer Verlag
DOI: 10.1007/s12104-021-10005-y

Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

Autorzy: Laura Boi, Augusta Pisanu, Maria Francesca Palmas, Giuliana Fusco, Ezio Carboni, Maria Antonietta Casu, Valentina Satta, Maria Scherma, Elzbieta Janda, Ignazia Mocci, Giovanna Mulas, Anna Ena, Saturnino Spiga, Paola Fadda, Alfonso De Simone, Anna R. Carta
Opublikowane w: International Journal of Molecular Sciences, Numer 21/22, 2020, Strona(/y) 8535, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21228535

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

Autorzy: Wing K. Man, Bogachan Tahirbegi, Michail D. Vrettas, Swapan Preet, Liming Ying, Michele Vendruscolo, Alfonso De Simone, Giuliana Fusco
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-21027-4

Membrane Interactions and Toxicity by Misfolded Protein Oligomers

Autorzy: Mario Gonzalez-Garcia, Giuliana Fusco, Alfonso De Simone
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer 9, 2021, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2021.642623

In Silico Study of the Mechanism of Binding of the N-Terminal Region of α Synuclein to Synaptic-Like Membranes

Autorzy: Carlos Navarro-Paya, Maximo Sanz-Hernandez, Alfonso De Simone
Opublikowane w: Life, Numer 10/6, 2020, Strona(/y) 98, ISSN 2075-1729
Wydawca: MDPI
DOI: 10.3390/life10060098

Plasticity of Membrane Binding by the Central Region of α-Synuclein

Autorzy: Navarro-Paya C, Sanz-Hernandez M, De Simone A.
Opublikowane w: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Wydawca: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.857217

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

Autorzy: Amberley D. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco, Neeleema Seetaloo, Anass Chiki, Philippa J. Woodhams, Ioanna Mela, Hilal A. Lashuel, Jonathan J. Phillips, Alfonso De Simone, Frank Sobott, Gabriele S. Kaminski Schierle
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-16564-3

Enhancing Biomolecular Simulations with Hybrid Potentials Incorporating NMR Data

Autorzy: Qi G, Michail D. Vrettas, Biancaniello C, Sanz-Hernandez M, Cafolla CT, Morgan JWR, Wang Y, De Simone A, Wales DJ.
Opublikowane w: Journal of Chemical Theory and Computations, 2022, ISSN 1549-9618
Wydawca: American Chemical Society
DOI: 10.1021/acs.jctc.2c00657

Mechanism of misfolding of the human prion protein revealed by a pathological mutation

Autorzy: Máximo Sanz-Hernández, Joseph D. Barritt, Jens Sobek, Simone Hornemann, Adriano Aguzzi, Alfonso De Simone
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 118/12, 2021, Strona(/y) e2019631118, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2019631118

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Autorzy: Phuong H. Nguyen, Ayyalusamy Ramamoorthy, Bikash R. Sahoo, Jie Zheng, Peter Faller, John E. Straub, Laura Dominguez, Joan-Emma Shea, Nikolay V. Dokholyan, Alfonso De Simone, Buyong Ma, Ruth Nussinov, Saeed Najafi, Son Tung Ngo, Antoine Loquet, Mara Chiricotto, Pritam Ganguly, James McCarty, Mai Suan Li, Carol Hall, Yiming Wang, Yifat Miller, Simone Melchionna, Birgit Habenstein, Stepan Timr, Jiaxi
Opublikowane w: Chemical Reviews, Numer 121/4, 2021, Strona(/y) 2545-2647, ISSN 0009-2665
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrev.0c01122

Thermal tuning of protein hydration in a hyperthermophilic enzyme

Autorzy: Giuliana Fusco, Carmen Biancaniello, Michail Vrettas, Alfonso De Simone
Opublikowane w: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Wydawca: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.1037445

A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

Autorzy: Wing K. Man, Alfonso De Simone, Joseph D. Barritt, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
Opublikowane w: Frontiers in Neuroscience, Numer 14, 2020, ISSN 1662-453X
Wydawca: Frontiers
DOI: 10.3389/fnins.2020.00018

The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes

Autorzy: Fusco G, Bemporad F, Chiti F, Dobson CM, De Simone A.
Opublikowane w: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Wydawca: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.981312

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