Objective
The adverse effects of pharmaceuticals on the central or peripheral nervous systems are poorly predicted by the current in vitro and in vivo preclinical studies performed during Research and Development (R&D) process. Therefore, increasing the predictivity of the preclinical toolbox is a clear need, and would benefit to human volunteers/patients (safer drugs) and Pharmaceutical Industry (reduced attrition). By combining top level scientists in neurobiology/toxicology with successful software developers, the NeuroDeRisk | Neurotoxicity De-Risking in Preclinical Drug Discovery Consortium will aim at tackling three of the most challenging adverse effects: seizures, psychological/psychiatric changes, and peripheral neuropathies. Our approach will be global, starting with an in-depth evaluation of knowledge on mechanisms of neurotoxicity (biological pathways as well as chemical structures and descriptors, using in particular historical data). Then we will search for innovative tools, assays and studies covering in silico, in vitro and in vivo approaches. This will include in particular: molecular design platform, artificial intelligence, human induced pluripotent stem cells, blood-brain-barrier models, immunohistochemistry, transcriptomics, RNA editing biomarkers, video-monitoring and telemetry of animals, pharmacokinetics, etc. The last step will aim at combining these tools in an integrated platform for better risk-assessment and decision-points throughout R&D process, and thus better protection of human volunteers and patients.
Field of science
- /medical and health sciences/medical biotechnology/cells technologies/stem cells
- /natural sciences/computer and information sciences/artificial intelligence
- /natural sciences/biological sciences/neurobiology
Call for proposal
H2020-JTI-IMI2-2017-13-two-stage
See other projects for this call
Funding Scheme
IMI2-RIA - Research and Innovation actionCoordinator
1010 Wien
Austria
Participants (17)
1090 Wien
52600 Belgrade
2344 Maria Enzersdorf
70211 Kuopio
50121 Florence
4051 401 Porto
751 05 Uppsala
13790 Peynier
63000 Clermont-ferrand
167 77 Athina
91380 Chilly Mazarin
151 85 Sodertaelje
53711 Madison Wi
08889 Whitehouse Station Nj
4056 Basel
CT13 9NJ Sandwich
1070 Bruxelles