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ARCHITECTURE AND TOOLS FOR THE QUERY OF ANTIBODY AND T-CELL RECEPTOR SEQUENCING DATA REPOSITORIES FOR ENABLING IMPROVED PERSONALIZED MEDICINE AND IMMUNOTHERAPY

Project information

Grant agreement ID: 825821

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.3.1.5.

  • Overall budget:

    € 8 505 675

  • EU contribution

    € 7 856 925

Coordinated by:

BAR ILAN UNIVERSITY

Israel

Objective

Background: Many cutting-edge therapies rely on manipulating the adaptive immune system, which has evolved a vast diversity (repertoire) of immune receptors to recognize and remove pathogens and cancer cells. The sequence-data sets characterizing this Adaptive Immune Receptor Repertoire (i.e., AIRR-seq data) have the potential to revolutionize vaccine research and the development of therapies against autoimmune diseases and cancer; however, AIRR-seq data are typically stored and curated by individual labs, using a variety of tools and technologies. Sharing these data in a common way across disease studies, labs, and institutions around the world will improve our ability to recognize patterns in basic research and clinical trials, and increase our confidence in these patterns. The existing iReceptor Platform uses community-developed standards to facilitate sharing of AIRR-seq data by enabling queries across a system of distributed data repositories.

Project: The iReceptor Plus consortium of researchers from Europe and Canada will address several key challenges to optimally sharing AIRR-seq data among public and industrial partners: protecting patient privacy and the intellectual property of partners, performing complex analyses on data brought together from many sources, and expanding the size and number of repositories that can be integrated in the network.

Impact: The iReceptor Plus project will facilitate sharing of AIRR-seq data among multiple institutions, including biopharmaceutical companies and researchers working with human confidential data, across multiple diseases, treatments and populations. This will lead to a better understanding of the causes of infectious and autoimmune diseases and cancer, which can lead to early detection and suggest novel therapies. These improvements will reduce the social and economic burden of these diseases, advance Europe and Canada’s leadership role in immunotherapy, and contribute to improved patient care worldwide

Coordinator

BAR ILAN UNIVERSITY

Address

Bar Ilan University Campus
52900 Ramat Gan

Israel

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 975 750

Participants (19)

Simon Fraser University

Canada

SORBONNE UNIVERSITE

France

EU Contribution

€ 647 000

THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Canada

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

EU Contribution

€ 649 750

ACONDICIONAMIENTO TARRASENSE ASSOCIACION

Spain

EU Contribution

€ 280 625

INESC TEC - INSTITUTO DE ENGENHARIADE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA

Portugal

EU Contribution

€ 495 250

UNIVERSITY OF HAIFA

Israel

EU Contribution

€ 979 375

UNIVERSITETET I OSLO

Norway

EU Contribution

€ 180 000

MITMYNID LDA

Portugal

EU Contribution

€ 301 250

ASCORA GMBH

Germany

EU Contribution

€ 508 750

MEDGENOME INC

United States

EU Contribution

€ 150 250

INFINIDAT LTD

Israel

EU Contribution

€ 386 750

10X GENOMICS, INC.

United States

EU Contribution

€ 150 250

CLALIT HEALTH SERVICES

Israel

EU Contribution

€ 167 500

THE UNIVERSITY OF TEXAS SYSTEM

United States

EU Contribution

€ 679 800

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

France

EU Contribution

€ 556 875

OSLO UNIVERSITETSSYKEHUS HF

Norway

EU Contribution

€ 180 000

TIME.LEX

Belgium

EU Contribution

€ 265 000

INTERTEAM LTD

Israel

EU Contribution

€ 302 750

Project information

Grant agreement ID: 825821

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.3.1.5.

  • Overall budget:

    € 8 505 675

  • EU contribution

    € 7 856 925

Coordinated by:

BAR ILAN UNIVERSITY

Israel