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A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

Objective

Rapid progress in information and biotechnologies offers the promise of better, personalized health strategies using rich phenotypic, environmental and molecular (omics) profiles of every individual. To capitalize on this great promise, key challenge is to relate these profiles to health and disease while accounting for high diversity in individuals, populations and environments. Both Europe and Canada have long-term investments in population-based prospective cohort studies providing essential longitudinal data. These data must be analysed in unison to reach statistical power, however, presently cohort data repositories are scattered, hard to search and integrate, and data protection and governance rules discourage central pooling.

EUCAN-Connect will enable large-scale integrated cohort data analysis for personalized and preventive healthcare across EU and Canada. This will be based on an open, scalable data platform for cohorts, researchers and networks, incorporating FAIR principles (Findable, Accessible, Interoperable, Reusable) for optimal reuse of existing data, and building on maturing federated technologies, with sensitive data kept locally and only results being shared and integrated, in line with key ELSI and governance guidelines. Widespread uptake will be promoted via beyond state-of-the-art research in close collaboration with leading cohort networks, focused on early-life origins of cardio-metabolic, developmental, musculoskeletal and respiratory health and disease impacting human life course.

To address challenges of sustainability and curation, we will deliver innovative solutions for distributed, low-cost data harvesting and preservation, community curation/harmonization, privacy protection, open source bioinformatics toolbox development, and international governance. EUCAN-Connect platform and collaborations will be coordinated through BBMRI-ERIC (EU) and Maelstrom Research (Canada) to sustain long-term benefits to science and citizens worldwide.

Programme(s)

H2020-EU.3.1.5. - Methods and data

Topic(s)

SC1-BHC-05-2018 - International flagship collaboration with Canada for human data storage, integration and sharing to enable personalised medicine approaches

Call for proposal

H2020-SC1-2018-Single-Stage-RTD

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Funding Scheme

RIA - Research and Innovation action
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Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN

Address

Hanzeplein 1
9713 Gz Groningen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 643 000

Website

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Participants (12)

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The Research Institute of the Mc Gill University Health Centre

Canada

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 717 268,75

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

EU Contribution

€ 796 125

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 521 875

BIOBANKS AND BIOMOLECULAR RESOURCESRESEARCH INFRASTRUCTURE CONSORTIUM(BBMRI-ERIC)

Austria

EU Contribution

€ 399 326,25

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 477 125

EPIGENY

France

EU Contribution

€ 366 250

INESC TEC - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA

Portugal

EU Contribution

€ 231 250

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA

Spain

EU Contribution

€ 224 740

OULUN YLIOPISTO

Finland

EU Contribution

€ 264 183,75

STICHTING VUMC

Netherlands

EU Contribution

€ 222 935

INSTITUTO DE SAUDE PUBLICA DA UNIVERSIDADE DO PORTO

Portugal

EU Contribution

€ 135 625

Project information

Grant agreement ID: 824989

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.5.

  • Overall budget:

    € 6 717 953,75

  • EU contribution

    € 5 999 703,75

Coordinated by:

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

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Last update: 15 April 2019

Record number: 221475