Role of proteotoxicity in mitochondrial dysfunction linked to Parkinson's disease
Alpha-synuclein (αSyn) aggregates form insoluble fibrils in pathological conditions such as Parkinson's disease (PD). Mitochondrial dysfunction is implicated in PD, but a detailed understanding of the cause and effect of αSyn toxicity is lacking. The EU-funded PD-MitoQUANT project aims to elucidate the role of mitochondrial dysfunction in PD, identify and validate novel disease biomarkers and propose innovative therapeutic targets. The project consortium includes partners from academia and industry with multidisciplinary expertise in the fields of αSyn biochemistry, stem cell-derived PD models, mitochondrial function and structural analysis, mitochondrial function systems biology and in vivo animal models. The project is focussing on a quantitative description and integrated analysis of mitochondrial function and its relation to proteotoxicity.
Call for proposal
See other projects for this call
Funding SchemeIMI2-RIA - Research and Innovation action
49131 Petach Tivka
SW1V 1EJ London
6525 GA Nijmegen