Skip to main content

PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease

Project description

Role of proteotoxicity in mitochondrial dysfunction linked to Parkinson's disease

Alpha-synuclein (αSyn) aggregates form insoluble fibrils in pathological conditions such as Parkinson's disease (PD). Mitochondrial dysfunction is implicated in PD, but a detailed understanding of the cause and effect of αSyn toxicity is lacking. The EU-funded PD-MitoQUANT project aims to elucidate the role of mitochondrial dysfunction in PD, identify and validate novel disease biomarkers and propose innovative therapeutic targets. The project consortium includes partners from academia and industry with multidisciplinary expertise in the fields of αSyn biochemistry, stem cell-derived PD models, mitochondrial function and structural analysis, mitochondrial function systems biology and in vivo animal models. The project is focussing on a quantitative description and integrated analysis of mitochondrial function and its relation to proteotoxicity.

Call for proposal

H2020-JTI-IMI2-2017-13-two-stage
See other projects for this call

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Address
Saint Stephen's Green 123
2 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 088 108,20

Participants (14)

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
France
EU contribution
€ 849 895,31
Address
Boulevard De L'hopital 47
75013 Paris
Activity type
Research Organisations
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany
EU contribution
€ 537 652,25
Address
Venusberg-campus 1/99
53127 Bonn
Activity type
Research Organisations
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 541 145,96
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 358 277,51
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
EU contribution
€ 0
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
GENEXPLAIN GMBH
Germany
EU contribution
€ 147 921,28
Address
Am Exer 19 B
38302 Wolfenbuttel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MIMETAS BV
Netherlands
EU contribution
€ 249 228,10
Address
Jh Oortweg 19
2333CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 158 462,51
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
PINTAIL LTD
Ireland
EU contribution
€ 165 946,24
Address
Springhill Avenue 77
A94 K542 Blackrock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TEVA PHARMACEUTICAL INDUSTRIES LIMITED
Israel
EU contribution
€ 0
Address
5 Basel St
49131 Petach Tivka
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
H. LUNDBECK AS
Denmark
EU contribution
€ 0
Address
Ottiliavej 7-9
2500 Valby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UCB BIOPHARMA
Belgium
EU contribution
€ 0
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PARKINSON'S DISEASE SOCIETY OF THEUNITED KINGDOM LBG
United Kingdom
EU contribution
€ 0
Address
Vauxhall Bridge Raod 215
SW1V 1EJ London
Activity type
Other
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
EU contribution
€ 401 297,64
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Activity type
Higher or Secondary Education Establishments