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PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease

Project description

Role of proteotoxicity in mitochondrial dysfunction linked to Parkinson's disease

Alpha-synuclein (αSyn) aggregates form insoluble fibrils in pathological conditions such as Parkinson's disease (PD). Mitochondrial dysfunction is implicated in PD, but a detailed understanding of the cause and effect of αSyn toxicity is lacking. The EU-funded PD-MitoQUANT project aims to elucidate the role of mitochondrial dysfunction in PD, identify and validate novel disease biomarkers and propose innovative therapeutic targets. The project consortium includes partners from academia and industry with multidisciplinary expertise in the fields of αSyn biochemistry, stem cell-derived PD models, mitochondrial function and structural analysis, mitochondrial function systems biology and in vivo animal models. The project is focussing on a quantitative description and integrated analysis of mitochondrial function and its relation to proteotoxicity.

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Net EU contribution
€ 1 088 108,20
Address
St Stephen's Green 123
2 Dublin
Ireland

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Region
Ireland Northern and Western Border
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 088 108,20

Participants (14)

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
France
Net EU contribution
€ 849 895,31
Address
Boulevard De L'hopital 47
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 849 895,31
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany
Net EU contribution
€ 537 652,25
Address
Venusberg-campus 1/99
53127 Bonn

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Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 537 652,25
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Net EU contribution
€ 541 145,96
Address
Piazzale Aldo Moro 7
00185 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Other funding
€ 541 145,96
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 358 277,51
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 358 277,51
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
Net EU contribution
€ 0,00
Address
Houtlaan 4
6525 XZ Nijmegen
Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
GENEXPLAIN GMBH
Germany
Net EU contribution
€ 147 921,28
Address
Am Exer 19 B
38302 Wolfenbuttel

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Niedersachsen Braunschweig Wolfenbüttel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 147 921,28
MIMETAS BV
Netherlands
Net EU contribution
€ 249 228,10
Address
De Limes 7
2342 DH Oegstgeest

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 249 228,10
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 158 462,51
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 158 462,51
PINTAIL LTD
Ireland
Net EU contribution
€ 165 946,24
Address
Springhill Avenue 77
A94 K542 Blackrock

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Eastern and Midland Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 165 946,24
TEVA PHARMACEUTICAL INDUSTRIES LIMITED
Israel
Net EU contribution
€ 0,00
Address
5 Basel St
49131 Petach Tivka

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
H. LUNDBECK AS
Denmark
Net EU contribution
€ 0,00
Address
Ottiliavej 7-9
2500 Valby

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Region
Danmark Hovedstaden Byen København
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UCB BIOPHARMA
Belgium
Net EU contribution
€ 0,00
Address
Allee De La Recherche 60
1070 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
PARKINSON'S DISEASE SOCIETY OF THEUNITED KINGDOM LBG
United Kingdom
Net EU contribution
€ 0,00
Address
Vauxhall Bridge Raod 215
SW1V 1EJ London

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Region
London Inner London — West Westminster
Activity type
Other
Other funding
€ 0,00
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Net EU contribution
€ 401 297,64
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 401 297,64