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Targeting Purinergic Pathway in drug-resistant epilepsy using human Neurons and Glia.

Project description

A novel target for epilepsy treatment

Epilepsy affects millions of people worldwide nearly a third of which do not respond to available treatments for controlling the recurrent seizures. The ATP-gated P2X7 receptor (P2X7R) has spurred great interest as a new therapeutic target for epilepsy, but first, the cells associated with pathological P2X7R activation must be identified. For this purpose, the EU-funded TaPPiNG-EPI project will use human-induced pluripotent stem cell-derived neurons and glia, as well as resected brain tissue from patients with epilepsy, to investigate the cell-specific alterations linked with the P2X7R pathway. Pharmacological targeting of the pathway using specific drugs will unveil the therapeutic potential of P2X7R in epilepsy.

Call for proposal

H2020-MSCA-IF-2018
See other projects for this call

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Address
Saint Stephen's Green 123
2 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 196 590,72