A novel target for epilepsy treatment
Epilepsy affects millions of people worldwide nearly a third of which do not respond to available treatments for controlling the recurrent seizures. The ATP-gated P2X7 receptor (P2X7R) has spurred great interest as a new therapeutic target for epilepsy, but first, the cells associated with pathological P2X7R activation must be identified. For this purpose, the EU-funded TaPPiNG-EPI project will use human-induced pluripotent stem cell-derived neurons and glia, as well as resected brain tissue from patients with epilepsy, to investigate the cell-specific alterations linked with the P2X7R pathway. Pharmacological targeting of the pathway using specific drugs will unveil the therapeutic potential of P2X7R in epilepsy.
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