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Decoding Context-Dependent Genetic Networks in vivo

Project description

Functional genetic architecture of complex tissues in vivo

The EU-funded DECODE project will employ leading-edge system genetics methods to study molecular determinants for cell fate specification in Arabidopsis and Drosophila, as the plant and animal models, to decode context-dependent genetic networks in vivo. Project partners with expertise in model organism genetics and cellular phenotyping, single-cell genomics, statistics, and computational biology will create functional genetic maps using CRISPR/Cas9-based knockout perturbations in vivo combined with single-cell expression profiling and imaging. The thousands of conditional knockouts and several million single-cell transcriptome profiles with high-resolution imaging will create the largest single-cell perturbation map of the model organism and provide fundamental insights into the genetic architecture of complex tissues.

Call for proposal

ERC-2018-SyG
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Host institution

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Germany
Activity type
Research Organisations
EU contribution
€ 4 042 500

Beneficiaries (3)

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 4 042 500
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 2 812 500
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 3 770 000
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations