Functional genetic architecture of complex tissues in vivo
The EU-funded DECODE project will employ leading-edge system genetics methods to study molecular determinants for cell fate specification in Arabidopsis and Drosophila, as the plant and animal models, to decode context-dependent genetic networks in vivo. Project partners with expertise in model organism genetics and cellular phenotyping, single-cell genomics, statistics, and computational biology will create functional genetic maps using CRISPR/Cas9-based knockout perturbations in vivo combined with single-cell expression profiling and imaging. The thousands of conditional knockouts and several million single-cell transcriptome profiles with high-resolution imaging will create the largest single-cell perturbation map of the model organism and provide fundamental insights into the genetic architecture of complex tissues.
Call for proposal
See other projects for this call