Translational Safety Biomarker Pipeline (TransBioLine): Enabling development and implementation of novel safety biomarkers in clinical trials and diagnosis of disease

Project description

Novel safety biomarkers for drug development

Testing the safety of drugs is the most important aspect in the drug development pipeline. Although various safety biomarkers have been proposed, substantial sample sizes are required for their validation. The EU-funded TransBioLine project will capitalise on existing data, resources and international collaborations to establish robust biomarkers for use in drug development. Researchers will also develop and validate assays for new safety biomarkers and implement circulating miRNAs as tissue- and mechanism-specific diagnostic tools. Ultimately, the aim is to obtain approval of safety biomarkers as qualified drug development tools by key regulatory authorities such as the EMA and FDA.

Programme(s)

• H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2)

Topic(s)

• IMI2-2017-13-11 - Translational Safety Biomarker Pipeline (TransBioLine): Enabling development and implementation of novel safety biomarkers in clinical trials and diagnosis of disease

Call for proposal

H2020-JTI-IMI2-2017-13-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

UNIVERSITAT ZURICH

Address

Ramistrasse 71
8006 Zurich
Switzerland

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 2 389 381

Participants (28)

UNIVERSIDAD DE MALAGA

Spain

EU contribution

€ 246 452

Address

Avda Cervantes, Num. 2
29016 Malaga

Activity type

Higher or Secondary Education Establishments

INFORMATION TECHNOLOGY FOR TRANSLATIONAL MEDICINE (ITTM) SA

Luxembourg

EU contribution

€ 624 125

Address

9 Avenue Des Hauts-forneaux
4362 Esch-sur-alzette

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

LANDSPITALI UNIVERSITY HOSPITAL

Iceland

EU contribution

€ 87 325

Address

Eiriksgata 5
101 Reykjavik

Activity type

Higher or Secondary Education Establishments

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU contribution

€ 443 450

Address

Geschwister Scholl Platz 1
80539 Muenchen

Activity type

Higher or Secondary Education Establishments

THE UNIVERSITY OF NOTTINGHAM

United Kingdom

EU contribution

€ 832 700

Address

University Park
NG7 2RD Nottingham

Activity type

Higher or Secondary Education Establishments

UNIVERSIDAD DE SALAMANCA

Spain

EU contribution

€ 69 500

Address

Calle Patio De Escuelas 1
37008 Salamanca

Activity type

Higher or Secondary Education Establishments

INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU FUNDACION

Spain

EU contribution

€ 182 600

Address

C Sant Quinti 77-79
08041 Barcelona

Activity type

Research Organisations

TAMIRNA GMBH

Austria

EU contribution

€ 1 231 000

Address

Leberstrasse 20/8
1110 Wien

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

SIGNATOPE GMBH

Germany

EU contribution

€ 1 990 000

Address

Markwiesenstr. 55
72770 Reutlingen

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

ABX CRO ADVANCED PHARMACEUTICAL SERVICES FORSCHUNGSGESELLSCHAFT MBH

Germany

EU contribution

€ 1 294 360

Address

Blasewitzer Str 78-80
01307 Dresden

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

METAHEPS GMBH

Germany

EU contribution

€ 284 000

Address

Am Klopferspitz 19
82152 Planegg

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

France

EU contribution

€ 81 400

Address

3 Avenue Victoria
75000 Paris

Activity type

Research Organisations

SYNAPSE RESEARCH MANAGEMENT PARTNERS SL

Spain

EU contribution

€ 900 000

Address

Calle Velazquez 94 Planta 1
28006 Madrid

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU contribution

€ 1 386 193,75

Address

Chariteplatz 1
10117 Berlin

Activity type

Higher or Secondary Education Establishments

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

EU contribution

€ 109 475

Address

Kings Gate
NE1 7RU Newcastle Upon Tyne

Activity type

Higher or Secondary Education Establishments

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU contribution

€ 940 250

Address

Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool

Activity type

Higher or Secondary Education Establishments

MLM MEDICAL LABS GMBH

Germany

EU contribution

€ 604 800

Address

Dohrweg 63
41066 Monchengladbach

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

UNIVERSITEIT LEIDEN

Netherlands

EU contribution

€ 34 000

Address

Rapenburg 70
2311 EZ Leiden

Activity type

Higher or Secondary Education Establishments

SERVICIO ANDALUZ DE SALUD

Spain

EU contribution

€ 188 946

Address

Avenida De La Constitucion 18
41071 Sevilla

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

PFIZER LIMITED

United Kingdom

EU contribution

€ 0

Address

Ramsgate Road
CT13 9NJ Sandwich

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

MERCK SHARP & DOHME CORP

United States

EU contribution

€ 0

Address

One Merck Drive
08889 Whitehouse Station Nj

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Eli Lilly and Company Limited

United Kingdom

EU contribution

€ 0

Address

Lilly House, Priestley Road
RG24 9NL Basingstoke

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

NOVARTIS PHARMA AG

Switzerland

EU contribution

€ 0

Address

Lichtstrasse 35
4056 Basel

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

F. HOFFMANN-LA ROCHE AG

Switzerland

EU contribution

€ 0

Address

Grenzacherstrasse 124
4070 Basel

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

JANSSEN PHARMACEUTICA NV

Belgium

EU contribution

€ 0

Address

Turnhoutseweg 30
2340 Beerse

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT

France

EU contribution

€ 0

Address

Pierre Brossolette 1
91380 Chilly Mazarin

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

THE CRITICAL PATH INSTITUTE (C-PATH) NON PROFIT CORPORATION

United States

EU contribution

€ 0

Address

E River Road 1730 200
85718 Tucson Az

Activity type

Other

UNIVERSITAET BERN

Switzerland

EU contribution

€ 80 040

Address

Hochschulstrasse 6
3012 Bern

Activity type

Higher or Secondary Education Establishments