CORDIS
EU research results

CORDIS

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iPS-derived MIcroglia and Neuroinflammation in Dementia

Project information

Grant agreement ID: 841665

Status

Ongoing project

  • Start date

    20 February 2020

  • End date

    19 February 2023

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 269 002,56

  • EU contribution

    € 269 002,56

Coordinated by:

UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA

Italy

Project description

English EN

Microglial proteins and Alzheimer's disease

As the global population ages, diseases associated with ageing increase in prevalence. Among them is the incurable Alzheimer's disease (AD), a debilitating neurodegenerative condition causing loss of memory and cognition. Recently, researchers identified a protective mutation in a gene associated with AD. The gene codes a protein abundant in microglia, cells that engulf and digest cellular debris and dead cells in the brain and spinal cord, playing an important role in immunity. iMIND is creating human microglial cell lines from both healthy and AD-derived stem cells. These will be edited to express the mutation. Studies may elucidate novel molecular mechanisms of AD and point to therapies.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA

Address

Via Dei Vestini 31
66013 Chieti

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 269 002,56

Partners (1)

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

United States

Project information

Grant agreement ID: 841665

Status

Ongoing project

  • Start date

    20 February 2020

  • End date

    19 February 2023

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 269 002,56

  • EU contribution

    € 269 002,56

Coordinated by:

UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA

Italy