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Organic Mesocrystals: Formation and controlling of oriented nanoparticles of molecular solids for drug development

Organic Mesocrystals: Formation and controlling of oriented nanoparticles of molecular solids for drug development

Objective

The OMECRY research action aims to enhance the dissolution of pharmaceutical solids in the form of mesocrystals, i.e. to promote the drug development. I will also investigate the formation mechanisms of the organic mesocrystals, and influence of the different additives on these processes. The low dissolution rate and poor aqueous solubility of emerging new drug candidates limit the formulation approaches, clinical application, and marketability in pharmaceutical industry. The preparation of active pharmaceutical ingredients (APIs) in the form of mesocrystals can enhance the dissolution rate suitable for drug delivery. The voids between highly oriented nanocrystals and high surface area of hierarchical structure in the non-classical pathway of mesocrystals formation play a role in the process. Different additives can be used to control the self-assembly of particles so that avoiding mesocrystals fusion into single crystals. A suitable additive can be screened through density functional theory calculations. The microstructure of mesocrystals and its transformation and particle growth can be investigated through time-dependent experiments using SEM, TEM and laser diffraction particle size analyser. Computed Tomography will be used for the first time to obtain the density mapping of mesocrystals surface in phase contrast mode. The dissolution rates and solubility of the mesocrystals are characterized and compared to its single crystals. The feasibility of drug dissolution will be investigated through in vitro studies. Although many inorganic mesocrystals has prepared for photocatalysis, energy storage applications, formation APIs in mesocrystals is a new strategy which provides insights that are needed for further understanding of mesocrystals formations thereby improve its applications especially for drug development.
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Coordinator

AALTO KORKEAKOULUSAATIO SR

Address

Otakaari 1
02150 Espoo

Finland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 202 680,96

Project information

Grant agreement ID: 842140

Status

Grant agreement signed

  • Start date

    1 August 2019

  • End date

    31 July 2021

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 202 680,96

  • EU contribution

    € 202 680,96

Coordinated by:

AALTO KORKEAKOULUSAATIO SR

Finland