CORDIS
EU research results

CORDIS

English EN
The neuroscience of tickling: cerebellar mechanisms and sensory prediction

The neuroscience of tickling: cerebellar mechanisms and sensory prediction

Objective

Detecting surprising events, such as the sudden approach of a predator or an unexpected touch, is crucial for the survival of all species. We aim to study neuronal mechanisms underlying surprising events. In order to predict upcoming events, mental models of future actions are essential. Where in the brain are such predictions and mental models created? The somatosensory cortex might contain a body model, in which superficial layers provide context and sensory memories, and inputs from deeper layers allow for simulating body movements. In rats, the somatosensory cortex is activated by tickling, which is a special form of unexpected touch containing elements of both sensory and social surprise. However, self-touch induces signals which prevent activation of the somatosensory cortex and prevent self-tickle. Where do these self-touch induced inhibitory signals come from? We hypothesize that the cerebellum is the source of self-touch induced signals. The cerebellum has reciprocal connections with key forebrain areas, including the somatosensory cortex. Combined with its known role in adapting action to sensory and internally generated events, the cerebellum seems well placed to aid in the processing of surprising events. We will test in mice and rats the hypothesis that the cerebellum plays a key role in processing unexpected events to modulate representations in somatosensory cortex. By combining the applicant’s experience in recordings from awake behaving mice, the expertise of the lab of Prof. Wang at Princeton University in cerebellar research with a focus on motor and non-motor function, and the expertise of the lab of Prof. Brecht at Humboldt-Universitaet in naturalistic systems neuroscience, we are well placed to study the cerebellar signals for sensory prediction. This study can help us to understand how we make sense of the complex environment around us by combining different inputs to form predictions and signal unexpected events during surprising situations.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

HUMBOLDT-UNIVERSITAET ZU BERLIN

Address

Unter Den Linden 6
10117 Berlin

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 246 669,12

Partners (1)

Sort alphabetically

Expand all

TRUSTEES OF PRINCETON UNIVERSITY

Project information

Grant agreement ID: 844318

Status

Grant agreement signed

  • Start date

    1 September 2019

  • End date

    31 August 2022

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 246 669,12

  • EU contribution

    € 246 669,12

Coordinated by:

HUMBOLDT-UNIVERSITAET ZU BERLIN

Germany