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Discovery and characterization of food bioactive compounds modulating the Pentose Phosphate Pathway against non-alcoholic fatty liver disease.

Project description

An enzyme to fight liver disease

Increasing incidence of obesity and type II diabetes has contributed to a very high prevalence of non-alcoholic fatty liver disease (NAFLD), an untreatable condition. Now affecting one in four people in Europe, NAFLD can progress to liver cirrhosis and liver cancer. It is also associated with a greater risk of cardiovascular diseases and other malignancies. There is a naturally occurring enzyme in the body that may play a role in halting disease progression. Food-PPP-NAFLD is using high-tech methods to investigate novel bioactive food compounds and previously identified pharmacological agents that boost this molecule's activity. Research outcomes will add new knowledge on the biochemical pathways involved in metabolic diseases.

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Net EU contribution
€ 172 932,48
Pabellon Central Del Antiguo Hospital De Cantoblan Edificio Numero 7- Carretera Madrid- Colmenar Viejo--kilometro 14
28049 Madrid

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Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00