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Integrated IMMUnoprofiling of large adaptive CANcer patients cohorts

Objective

IMMUcan proposes an inclusive and integrated European immuno-oncology platform. IMMUcan will access high-quality human biological material (tissue, blood, stool and saliva) and clinical data from patients with colorectal, lung, head & neck, breast, gastric cancers and immune checkpoints inhibitors failures. We have assembled a strong consortium with ten expert clinical centers, access to large volumes of the required tumor types. IMMUcan will mobilize the majority of academic trials running or expected to start recruiting patients during the project period. A centralized workflow for samples, via a state-of-the-art biobank will increase reproducibility as all tissues will be processed and stored in a uniform way, following proofed SOPs. The project will perform in depth immunoprofiling with cutting edge technologies including CyTOFF, single cell RNA-seq, peptidogenomics or microbiome analysis. IMMUcan will analyze the data in order to understand the host/tumour interaction in the absence of treatment (naïve population) and with treatment (patients in follow-up) to identify potential predictive biomarker for response to immunotherapy, or develop rationale for combination therapies. IMMUcan will provide an IT platform and legal/ethical contractual framework where participants from both academia and industry can pursue their own independent investigations utilizing the IMMUcan data and effectively testing and improving the functioning and relevance of the database. A sustainability plan will be developed to ensure the collection of follow-up data and the accessibility of the data platform. The use of the data generating throughout this project, for future research, will be supported.

Field of science

  • /medical and health sciences/basic medicine/immunology/immunotherapy
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /social sciences/other social sciences/social sciences interdisciplinary/sustainable development
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

H2020-JTI-IMI2-2017-13-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL
Address
Avenue E. Mounier 83
1200 Brussels
Belgium
Activity type
Research Organisations
EU contribution
€ 7 246 773,75

Participants (27)

SIB INSTITUT SUISSE DE BIOINFORMATIQUE
Switzerland
EU contribution
€ 1 323 000
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
EU contribution
€ 1 460 332,90
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
LUXEMBOURG INSTITUTE OF HEALTH
Luxembourg
EU contribution
€ 2 749 727,35
Address
Val Fleuri 84
1526 Luxembourg
Activity type
Research Organisations
FORUM EUROPEEN DES PATIENTS (FPE)
Luxembourg
EU contribution
€ 250 000
Address
Rue Dicks 14
1417 Luxembourg
Activity type
Other
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 1 712 880
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 765 066
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
LIGUE NATIONALE CONTRE LE CANCER
France
EU contribution
€ 120 000
Address
14 Rue Corvisart
75013 Paris
Activity type
Research Organisations
INSTITUT JULES BORDET
Belgium
EU contribution
€ 20 000
Address
Rue Heger Bordet 1
1000 Bruxelles
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 160 000
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
INSTITUT CURIE
France
EU contribution
€ 410 000
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
CENTRE DE LUTTE CONTRE LE CANCER LEON BERARD
France
EU contribution
€ 100 000
Address
Rue Laennec 28
69373 Lyon
Activity type
Research Organisations
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 573 700
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
DE DUVE INSTITUTE AISBL
Belgium
EU contribution
€ 0
Address
Avenue Hippocrate 75/50
1200 Bruxelles
Activity type
Research Organisations
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 20 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 190 200
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
OWKIN FRANCE
France
EU contribution
€ 0
Address
12 Rue Martel
75010 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 100 000
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 628 320
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN
Germany
EU contribution
€ 0
Address
Frankfurter Strasse 250
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ABBVIE INC
United States
EU contribution
€ 0
Address
North Waukegan Road 1
60064 North Chicago Il
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BAYER AKTIENGESELLSCHAFT
Germany
EU contribution
€ 0
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Eli Lilly and Company Limited
United Kingdom
EU contribution
€ 0
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
EU contribution
€ 0
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 0
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 0
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
France
EU contribution
€ 0
Address
Rue Carnot 50
92284 Suresnes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DE RECHERCHE PIERRE FABRESAS
France
EU contribution
€ 0
Address
Place Abel Gance 45
92100 Boulogne Billancourt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)