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Hydrogen Bonding Phase Transfer Catalysis

Hydrogen Bonding Phase Transfer Catalysis

Objective

The objective of the research described in this proposal is to develop a new mode of activation for catalysis leading to more sustainable catalytic processes using abundant feedstock materials. By merging hydrogen bonding and phase transfer catalysis, we propose that hydrogen bonding of an insoluble unreactive anionic nucleophile with a hydrogen bond donor catalyst will form a soluble and reactive entity now capable of carbon-nucleophile bond formation with concomitant release of the hydrogen bond donor catalyst. This activation mode is applicable to nucleophiles as simple as feedstock inorganic salts enabling challenging asymmetric bond-forming reactions in a general and predictable fashion. Inexpensive lost nucleophiles currently unusable due to poor solubility and reactivity will be reclaimed as effective reagents for asymmetric catalysis. Common inorganic salts such as sodium chloride or potassium fluoride will be transformed into high-value products such as complex pharmaceutical and agrochemical products applying operationally simple and cost effective protocols. Synergistic catalysis whereby hydrogen bonding phase transfer catalysis will work in concert with an additional catalytic cycle will be implemented to introduce new chemical transformations with these feedstock reagents, improve efficiency, and create catalytic enantioselectivity where stereocontrol is absent or challenging. This research will require the development of high performance catalysts and the understanding of catalytic mechanisms applying structural, kinetics, and computational studies. HBPTC is expected to expand the field of catalysis, and rival the efficiency of some of the most active metal, organocatalyst and biocatalyst known to date.
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Host institution

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Address

Wellington Square University Offices
Ox1 2jd Oxford

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 499 070

Beneficiaries (1)

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 2 499 070

Project information

Grant agreement ID: 832994

Status

Grant agreement signed

  • Start date

    1 July 2019

  • End date

    30 June 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 499 070

  • EU contribution

    € 2 499 070

Hosted by:

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom