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EVOLUTION OF CYANIDE METABOLIMS IN APOSEMATIC BUTTERFLIES: from gene characterization to community ecology

EVOLUTION OF CYANIDE METABOLIMS IN APOSEMATIC BUTTERFLIES: from gene characterization to community ecology

Objective

The colourful and toxic Heliconius butterflies are well-established models to study evolution of aposematims and mimicry, yet the genetic basis of their toxicity and how this varies in different populations remains unknown. Heliconius are toxic butterflies because they contain cyanide-releasing compounds called cyanogenic glucosides, which they can both biosynthesize or uptake from Passiflora plants, their co-evolutionary partner, during larval feeding. This multidisciplinary project brings together ecology, genetics, biochemistry and evolutionary biology to investigate how toxicity and interactions with Passiflora plants has shaped the evolution of these butterflies. Thus, I will combine the gene-editing technology CRISPR-Cas with different OMICs approaches (metabolomics, transcriptomics and phenomics) to (1) decipher the genetic and phenotipic bases of cyanogenesis in Heliconius butterflies and (2) unravel the evolutionary trajectory of this defence system in the Heliconiine tribe. Moreover, I will also (3) establish how cyanogenesis vary within and between tropical and subtropical heliconiine-Passiflora communities of the Brazilian Atlantic Forest, a biodiversity hotspot endangered by extreme deforestation.
This project will give me the unique opportunity to expand my knowledge and skills repertoire on genetics, ecology, evolutionary biology and bioinformatics. I will be trained in advanced techniques such CRISPR-Cas, gene expression analysis, R programing, statistical methods applied to community ecology and matabolomics, etc. Also, during this fellowship I will excel my teaching/supervision, project management and communication abilities. All these expertise will be extremely valuable for the execution of the project and will bring great progress to my career development, increasing my chance of of reaching a long-term position in academia.
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Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Address

Trinity Lane The Old Schools
Cb2 1tn Cambridge

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 224 933,76

Project information

Grant agreement ID: 841230

Status

Grant agreement signed

  • Start date

    1 January 2020

  • End date

    31 December 2021

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 224 933,76

  • EU contribution

    € 224 933,76

Coordinated by:

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom