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Defining and modulating the stress granule proteome as a therapeutic strategy in Amyotrophic Lateral Sclerosis

Project description

Stress granule composition study in the search for amyotrophic lateral sclerosis therapy

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with an unknown cause: 10 % of patients show familial inheritance (fALS), while 90 % exhibit a sporadic form of ALS (sALS). ALS patients demonstrate intracellular inclusions of the RNA binding protein TDP-43. The process of TDP-43 aggregation, especially in sALS, is not understood. Cellular stress results in the recruitment of TDP-43 and other ALS-associated proteins into transient stress granules. A microenvironment of stress granules with a high local concentration of TDP-43 is suggested as a cause for aggregation, which is prevented in healthy neurons. The EU-funded StressOME project will investigate the composition of stress granules to identify novel targets that affect TDP-43 aggregation in fALS and sALS.


Net EU contribution
€ 166 320,00
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Other funding
€ 0,00