CORDIS
EU research results

CORDIS

English EN
Deciphering the effects of locus coeruleus activity on whole-brain dynamics and neurovascular coupling

Deciphering the effects of locus coeruleus activity on whole-brain dynamics and neurovascular coupling

Objective

Locus coeruleus (LC) regulates vital autonomous and cognitive functions and has recently gained interest as a clinical target in neurodegenerative and psychiatric disorders. Previous studies have investigated the effect of LC activity on small groups of neurons and on endpoint behavior. However, LC’s widespread connections and broad downstream effects make a systems-level approach imperative for comprehensively understanding LC function. In LC-FMRI, we will perform highly specific optogenetic LC stimulation in mice and assess whole-brain responses and functional network reconfiguration using ultra-high field functional magnetic resonance imaging (fMRI). To decipher neural, astrocytic and vascular contributions to LC-induced fMRI responses, we will acquire simultaneous optical calcium recordings during fMRI. Experiments will be performed in awake mice to circumvent confounding effects of anesthesia on LC function. Finally, we will investigate how LC stimulation affects whole-brain dynamics and neurovascular coupling in the context of sensory processing. Our project will lay the foundation for studying how LC modulates whole-brain dynamics in health and disease using fMRI, with high potential for translation to human applications.

Coordinator

FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD

Address

Avenida Brasilia Centro De Investigacao Da Fundacao Champ Alimaud
1400 038 Lisboa

Portugal

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 147 815,04

Project information

Grant agreement ID: 867458

Status

Grant agreement signed

  • Start date

    1 November 2019

  • End date

    31 October 2021

Funded under:

H2020-EU.4.

  • Overall budget:

    € 147 815,04

  • EU contribution

    € 147 815,04

Coordinated by:

FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD

Portugal