CORDIS
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Advancing a GMMA-based vaccine against invasive non-typhoidal salmonellosis through Phase 1 trial in Europe and sub-Saharan Africa

Project description

English EN

Bacteria engineered to produce vaccines for invasive non-typhoidal salmonellosis

Invasive non-typhoidal Salmonella (iNTS) disease is a major emerging public health concern, particularly in sub-Saharan Africa, where cases of fatality greatly exceed those due to typhoid fever. Commonly affecting infants, young children, and immuno-compromised adults, morbidity occurs in 20-25 % of cases. Vaccines are desperately needed here. The EU-funded Vacc-iNTS project has used a new methodology for vaccine production that is simple, low-cost and very effective at inducing an immune response in the body. They are going to test it in Phase 1 clinical trials and are already planning data collection to support Phase 2 and 3 activities.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

SCLAVO VACCINES ASSOCIATION

Address

Piazza La Lizza 7
53100 Siena

Italy

Activity type

Research Organisations

EU Contribution

€ 1 152 311,51

Participants (11)

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GSK VACCINES INSTITUTE FOR GLOBAL HEALTH SRL

Italy

EU Contribution

€ 1 576 515

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 2 227 288,92

KENYA MEDICAL RESEARCH INSTITUTE

Kenya

EU Contribution

€ 107 575,33

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 545 942,74

UNIVERSITA DEGLI STUDI DI SIENA

Italy

EU Contribution

€ 341 017,51

PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE

Belgium

EU Contribution

€ 31 296,56

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 432 034,73

UNIVERSITY OF OTAGO

New Zealand

EU Contribution

€ 50 000

UNIVERSITE OUAGA I PROFESSEUR JOSEPH KI-ZERBO

Burkina Faso

EU Contribution

€ 192 980,26

KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY KUMASI

Ghana

EU Contribution

€ 194 226,17

MMGH CONSULTING GMBH

Switzerland

EU Contribution

€ 20 000

Project information

Grant agreement ID: 815439

Status

Ongoing project

  • Start date

    1 October 2019

  • End date

    30 September 2024

Funded under:

H2020-EU.3.1.3.

Coordinated by:

SCLAVO VACCINES ASSOCIATION

Italy