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BovReg - Identification of functionally active genomic features relevant to phenotypic diversity and plasticity in cattle

Objective

Despite the revolution in functional genome analysis a wide gap in understanding associations between the (epi)genome and complex phenotypes of interest currently remains and impedes efficient use of annotated genomes for precision breeding. The BovReg consortium will provide a comprehensive map of functionally active genomic features in cattle and how their (epi)genetic variation in beef and dairy breeds translates into phenotypes. This constitutes key knowledge for biology-driven genomic prediction needed by scientific and industry livestock communities. The BovReg brings together a critical mass of experts in ruminant research and beyond encompassing bioinformatics, molecular and quantitative genetics, animal breeding, reproductive physiology, ethics and social science. Our 20 partners from the EU, Canada and Australia form a global interdisciplinary team, which builds on previous and running national and EU-funded projects and many established industry cooperations. In BovReg we will generate functional genome data based on FAANG core assays from representative bovine tissues and newly established cell lines covering different ontological stages and phenotypes applying novel bioinformatic pipelines. We will establish detailed knowledge on traits related to robustness, health and biological efficiency in cattle. Data, knowledge and protocols will be deposited in European biological archives, aiming to set up and maintain a knowledge hub and establish gold standards. Long-term availability of data and targeted dissemination and communication activities are guaranteed by EMBL-EBI, FAANG and EAAP. Our biology-driven genomic prediction tools will integrate biological knowledge on regulatory genomic variation into genomic selection schemes for local and global cattle populations. This improved knowledge will be useful for re-focussing cattle production, fully taking into account societal awareness, environmental and animal-welfare aspects and bio-efficiency.

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /humanities/philosophy, ethics and religion/ethics
  • /natural sciences/biological sciences/genetics and heredity
  • /social sciences
  • /agricultural sciences/animal and dairy science/dairy
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/basic medicine/physiology
  • /social sciences/media and communications/library science/archives

Call for proposal

H2020-SFS-2018-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

LEIBNIZ-INSTITUT FUR NUTZTIERBIOLOGIE
Address
Wilhelm-stahl-allee 2
18196 Dummerstorf
Germany
Activity type
Research Organisations
EU contribution
€ 999 837,50

Participants (18)

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 299 943,75
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 492 000
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
DIAGENODE
Belgium
EU contribution
€ 107 125
Address
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 1 026 625
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 336 875
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 227 187,50
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
AARHUS UNIVERSITET
Denmark
EU contribution
€ 336 750
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
LUONNONVARAKESKUS
Finland
EU contribution
€ 267 850
Address
Latokartanonkaari 9
00790 Helsinki
Activity type
Research Organisations
INSTYTUT GENETYKI I BIOTECHNOLOGII ZWIERZAT POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 181 437,50
Address
Jastrzebiec, Ul. Postepu 36A
05-552 Magdalenka
Activity type
Research Organisations
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 188 832,50
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 538 120
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
FEDERAZIONE EUROPEA DI ZOOTECNICA
Italy
EU contribution
€ 125 250
Address
Via Giuseppe Tomassetti 3 A/1
00161 Roma
Activity type
Other
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA UNIVERSITY OF ALBERTA
Canada
EU contribution
€ 46 625
Address
Street 8625 112 Campus Tower 222 Research Services Office
T6G 2E1 Edmonton Alberta
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 435 422,74
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG
Germany
EU contribution
€ 82 312,50
Address
Universitaetsplatz 10
6108 Halle (Saale)
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LIMOGES
France
EU contribution
€ 136 062,50
Address
François Mitterrand 33
87032 Limoges
Activity type
Higher or Secondary Education Establishments
FACULDADE DE MEDICINA VETERINARIA
Portugal
EU contribution
€ 120 849,38
Address
Avenida Da Universidade Técnica - Polo Da Ajuda
1300-477 Lisboa
Activity type
Higher or Secondary Education Establishments
EDINETHICS LIMITED
United Kingdom
EU contribution
€ 44 352,96
Address
Dundonald Street 11 6
EH3 6RZ Edinburgh
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)