CORDIS
EU research results

CORDIS

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Generation of human steroid-producing organoids: a new approach to treat adrenal insufficiency

Project information

Grant agreement ID: 835533

Status

Ongoing project

  • Start date

    1 June 2019

  • End date

    31 May 2022

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 246 669,12

  • EU contribution

    € 246 669,12

Coordinated by:

TECHNISCHE UNIVERSITAET DRESDEN

Germany

Project description

English EN

Adrenal organoids genetically engineered

The adrenal glands are a pair of small walnut-sized organs sitting on top of your kidneys. They produce hormones essential for regulating metabolism, the immune system, blood pressure and your response to stress among others. Adrenal gland malfunction (adrenal insufficiency) can be life-threatening. The GHSO project is developing a novel adrenal-like organoid, a 3D self-assembled cellular structure derived from human embryonic stem cells with capacity to produce adrenal hormones. Once this ground-breaking task is accomplished, GHSO will create adrenal organoids genetically engineered with common mutations to exhibit adrenal insufficiency. In parallel, the in vitro organoids will be implanted in vivo to assess its capacity to reverse the disease, accelerating the development of more effective treatments for adrenal insufficiency.

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Coordinator

TECHNISCHE UNIVERSITAET DRESDEN

Address

Helmholtzstrasse 10
01069 Dresden

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 246 669,12

Partners (1)

CHILDREN'S HOSPITAL CORPORATION

United States

Project information

Grant agreement ID: 835533

Status

Ongoing project

  • Start date

    1 June 2019

  • End date

    31 May 2022

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 246 669,12

  • EU contribution

    € 246 669,12

Coordinated by:

TECHNISCHE UNIVERSITAET DRESDEN

Germany