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Stretchable mesh-electrodes interfacing human iPSC brain organoids

Project description

Novel soft electrodes 'cultured' with neural precursor cells will help study brain development

The brain contains about 100 billion neurons and about as many glial cells. These cells organise during development into structurally and functionally different tissues that work together to enable cognition, movement, sensation, emotion and more. Cell culture capabilities have progressed from individual cell colonies to functional 3D structures acting like organ systems (assembloids). Now, methods to study and manipulate assembloids must catch up. The STRELECOID project is planning to integrate novel stretchable mesh electrodes into neurospheres, free-form clusters of neural precursor cells. The electrodes will be used to apply physiological sensory input to the developing 'brain' or assembloid as well as to monitor changes. Ultimately, researchers hope to gain insight into often-debilitating neuropsychiatric conditions such as schizophrenia and autism.

Coordinator

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Net EU contribution
€ 251 002,56
Address
Via Morego 30
16163 Genova
Italy

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Region
Nord-Ovest Liguria Genova
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
United States
Net EU contribution
€ 0,00
Address
Serra Mall 450
94305 2004 Stanford

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 165 265,92