Novel soft electrodes 'cultured' with neural precursor cells will help study brain development
The brain contains about 100 billion neurons and about as many glial cells. These cells organise during development into structurally and functionally different tissues that work together to enable cognition, movement, sensation, emotion and more. Cell culture capabilities have progressed from individual cell colonies to functional 3D structures acting like organ systems (assembloids). Now, methods to study and manipulate assembloids must catch up. The STRELECOID project is planning to integrate novel stretchable mesh electrodes into neurospheres, free-form clusters of neural precursor cells. The electrodes will be used to apply physiological sensory input to the developing 'brain' or assembloid as well as to monitor changes. Ultimately, researchers hope to gain insight into often-debilitating neuropsychiatric conditions such as schizophrenia and autism.
Fields of science
- natural sciencesbiological sciencesneurobiology
- medical and health sciencesbasic medicineneurologyepilepsy
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesbasic medicineneurologyparkinson
Funding SchemeMSCA-IF-GF - Global Fellowships
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
94305 2004 Stanford
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