Health effects of cArdiac fluoRoscopy and MOderN radIotherapy in paediatriCs
Objective
The HARMONIC project builds on close collaboration between scientific and medical communities to contribute to improvements in the understanding of the health effects of medical ionising radiation exposure of paediatric patients, focusing on two distinct and complementary populations: (1) Paediatric patients undergoing modern radiotherapy (including proton therapy); (2) Paediatric patients undergoing interventional cardiology. Our project will provide additional insight into exposure to ionising radiation in childhood, exploring potential effects at very early ages, exposure to a wide range of doses from photons, protons and secondary neutrons radiation.
We aim at building European cohorts and registries for long term follow-up of paediatric patients treated with ionising radiation, both in cardiology and oncology settings, in the context of very rapid technology evolution. The study will use an integrated approach of conventional epidemiology, based on state-of-the art dosimetry, complemented by non-invasive imaging and molecular epidemiology to assess the following outcomes: endocrine dysfunctions, cardio and neurovascular diseases, societal impact and cancer. Complementary to this effort, we propose to investigate radiation-induced cellular responses in samples of blood and saliva, and the mechanisms involved in the processes that may lead to cancer and vascular diseases.
Ultimately, HARMONIC will develop tools and allow definition of guidelines on optimization techniques to guide treatments toward reduction of patient doses in paediatric cardiology and oncology.
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Address
C Rossello 132 Planta 05
08036 Barcelona
Spain
Activity type
Research Organisations
EU Contribution
€ 762 762,50
Participants (23)
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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU Contribution
€ 525 050
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU Contribution
€ 897 480
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU Contribution
€ 439 740
INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE
France
EU Contribution
€ 357 240
STUDIECENTRUM VOOR KERNENERGIE / CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE
Belgium
EU Contribution
€ 424 088,75
STOCKHOLMS UNIVERSITET
Sweden
EU Contribution
€ 239 687,50
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU Contribution
€ 171 653,75
AARHUS UNIVERSITETSHOSPITAL
Denmark
EU Contribution
€ 66 412,50
AARHUS UNIVERSITET
Denmark
EU Contribution
€ 241 250
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU Contribution
€ 176 215
CENTRE REGIONAL FRANCOIS BACLESSE
France
EU Contribution
€ 72 750
INSTITUT GUSTAVE ROUSSY
France
EU Contribution
€ 345 250
LEIBNIZ-INSTITUT FUR PRAVENTIONSFORSCHUNG UND EPIDEMIOLOGIE - BIPS GMBH
Germany
EU Contribution
€ 401 625
WESTDEUTSCHES PROTONENTHERAPIEZENTRUM ESSEN (WPE) GGMBH
Germany
EU Contribution
€ 388 787,50
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU Contribution
€ 295 551,25
LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY
Luxembourg
EU Contribution
€ 324 396,25
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
EU Contribution
€ 10 000
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU Contribution
€ 10 000
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU Contribution
€ 148 191,25
UNIVERSITETET I SOROST-NORGE
Norway
EU Contribution
€ 175 572,50
UNIVERSITAT ZURICH
Switzerland
EU Contribution
€ 300 000
STATE INSTITUTION RESEARCH CENTER FOR RADIATION MEDICINE OF THE ACADEMY OF MEDICAL SCIENCES OF UKRAINE
Ukraine
EU Contribution
€ 148 066,25
UNIVERSITE DE CAEN NORMANDIE
France
EU Contribution
€ 78 218,75
Project information
HARMONIC
Grant agreement ID: 847707
Status
Ongoing project
-
Start date
1 June 2019
-
End date
31 May 2024
Funded under:
H2020-Euratom-1.4.
-
Overall budget:
€ 6 999 988,75
-
EU contribution
€ 6 999 988,75
Project information
HARMONIC
Grant agreement ID: 847707
Status
Ongoing project
-
Start date
1 June 2019
-
End date
31 May 2024
Funded under:
H2020-Euratom-1.4.
-
Overall budget:
€ 6 999 988,75
-
EU contribution
€ 6 999 988,75
Deliverables
Deliverables not available
Publications
Publications not available
Project information
HARMONIC
Grant agreement ID: 847707
Status
Ongoing project
-
Start date
1 June 2019
-
End date
31 May 2024
Funded under:
H2020-Euratom-1.4.
-
Overall budget:
€ 6 999 988,75
-
EU contribution
€ 6 999 988,75
Project information
HARMONIC
Grant agreement ID: 847707
Status
Ongoing project
-
Start date
1 June 2019
-
End date
31 May 2024
Funded under:
H2020-Euratom-1.4.
-
Overall budget:
€ 6 999 988,75
-
EU contribution
€ 6 999 988,75
