CORDIS
EU research results

CORDIS

English EN
Health effects of cArdiac fluoRoscopy and MOderN radIotherapy in paediatriCs

Health effects of cArdiac fluoRoscopy and MOderN radIotherapy in paediatriCs

Objective

The increasing use of radiation-associated diagnostic and therapeutic procedures have contributed to the improvements of early diagnosis and survival of paediatric patients. While benefits to the patient outweigh the radiation associated risk, the late effects of exposure of children are particularly important to understand in populations with increased survival.
The HARMONIC project builds on close collaboration between scientific and medical communities to contribute to improvements in the understanding of the health effects of medical ionising radiation exposure of paediatric patients, focusing on two distinct and complementary populations: (1) Paediatric patients undergoing modern radiotherapy (including proton therapy); (2) Paediatric patients undergoing interventional cardiology. Our project will provide additional insight into exposure to ionising radiation in childhood, exploring potential effects at very early ages, exposure to a wide range of doses from photons, protons and secondary neutrons radiation.
We aim at building European cohorts and registries for long term follow-up of paediatric patients treated with ionising radiation, both in cardiology and oncology settings, in the context of very rapid technology evolution. The study will use an integrated approach of conventional epidemiology, based on state-of-the art dosimetry, complemented by non-invasive imaging and molecular epidemiology to assess the following outcomes: endocrine dysfunctions, cardio and neurovascular diseases, societal impact and cancer. Complementary to this effort, we propose to investigate radiation-induced cellular responses in samples of blood and saliva, and the mechanisms involved in the processes that may lead to cancer and vascular diseases.
Ultimately, HARMONIC will develop tools and allow definition of guidelines on optimization techniques to guide treatments toward reduction of patient doses in paediatric cardiology and oncology.

Coordinator

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA

Address

C Rossello 132 Planta 05
08036 Barcelona

Spain

Activity type

Research Organisations

EU Contribution

€ 762 762,50

Participants (23)

Sort alphabetically

Sort by EU Contribution

Expand all

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 525 050

UNIVERSITAETSKLINIKUM ESSEN

Germany

EU Contribution

€ 897 480

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

EU Contribution

€ 439 740

INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE

France

EU Contribution

€ 357 240

STUDIECENTRUM VOOR KERNENERGIE / CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE

Belgium

EU Contribution

€ 424 088,75

STOCKHOLMS UNIVERSITET

Sweden

EU Contribution

€ 239 687,50

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 171 653,75

AARHUS UNIVERSITETSHOSPITAL

Denmark

EU Contribution

€ 66 412,50

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 241 250

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 176 215

CENTRE REGIONAL FRANCOIS BACLESSE

France

EU Contribution

€ 72 750

INSTITUT GUSTAVE ROUSSY

France

EU Contribution

€ 345 250

LEIBNIZ-INSTITUT FUR PRAVENTIONSFORSCHUNG UND EPIDEMIOLOGIE - BIPS GMBH

Germany

EU Contribution

€ 401 625

WESTDEUTSCHES PROTONENTHERAPIEZENTRUM ESSEN (WPE) GGMBH

Germany

EU Contribution

€ 388 787,50

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 295 551,25

LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY

Luxembourg

EU Contribution

€ 324 396,25

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV

Netherlands

EU Contribution

€ 10 000

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 10 000

OSLO UNIVERSITETSSYKEHUS HF

Norway

EU Contribution

€ 148 191,25

UNIVERSITETET I SOROST-NORGE

Norway

EU Contribution

€ 175 572,50

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 300 000

STATE INSTITUTION RESEARCH CENTER FOR RADIATION MEDICINE OF THE ACADEMY OF MEDICAL SCIENCES OF UKRAINE

Ukraine

EU Contribution

€ 148 066,25

UNIVERSITE DE CAEN NORMANDIE

France

EU Contribution

€ 78 218,75

Project information

Grant agreement ID: 847707

Status

Ongoing project

  • Start date

    1 June 2019

  • End date

    31 May 2024

Funded under:

H2020-Euratom-1.4.

  • Overall budget:

    € 6 999 988,75

  • EU contribution

    € 6 999 988,75

Coordinated by:

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA

Spain