CORDIS
EU research results

CORDIS

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Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers

Project information

Grant agreement ID: 833613

Status

Ongoing project

  • Start date

    1 October 2019

  • End date

    30 September 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 201 875

  • EU contribution

    € 2 201 875

Hosted by:

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

Project description

English EN

A good look at chromatin remodelling

The long strands of DNA making up chromosomes are wrapped around proteins, sort of like thread on a spool, to fit them in the nucleus. This condensed form of DNA is called chromatin. For transcription and cell division to take place, the chromatin is 'remodelled' to enable access to DNA. This is a critical step in development, cell differentiation, and pathological processes such as cancer. However, its mechanisms remain poorly understood due to the structural complexity of the molecules. INO3D is employing Nobel-winning transmission electron cryomicroscopy (cryo-TEM) to provide a window on biological structures at the atomic level during chromatin remodelling by the INO80 molecule. Results could provide the first glimpses of INO80 in action.

Host institution

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Address

Geschwister Scholl Platz 1
80539 Muenchen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 201 875

Beneficiaries (1)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 2 201 875

Project information

Grant agreement ID: 833613

Status

Ongoing project

  • Start date

    1 October 2019

  • End date

    30 September 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 201 875

  • EU contribution

    € 2 201 875

Hosted by:

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany