CORDIS
EU research results

CORDIS

English EN

Characterization of the circadian chromatin landscape using a novel CRISPR/Cas9-guided proximity-labelling technique

Project information

Grant agreement ID: 846016

Status

Grant agreement signed

  • Start date

    1 September 2020

  • End date

    31 August 2022

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 162 806,40

  • EU contribution

    € 162 806,40

Coordinated by:

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

Project description

English EN

Mapping the body’s internal clock

Most living organisms have built-in clocks that synchronise with the seasons or the night and day cycle. The normal function of these 24-hour (or circadian) cycles is vital for humans, and continuing disruption of their rhythm results in serious illness. The actual process of circadian transmission is not well understood. The CLOCK project plans to use a CRISPR/Cas9-APEX labelling method (CASPEX) to map the three main circadian regulatory regions and to look for new clock modifiers. The outcome is expected to provide more understanding when treating the high incidence in the EU of pathologies linked to circadian rhythm disruption such as cancer, diabetes, and cardiovascular and neurodegenerative diseases.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Address

Chariteplatz 1
10117 Berlin

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 162 806,40

Project information

Grant agreement ID: 846016

Status

Grant agreement signed

  • Start date

    1 September 2020

  • End date

    31 August 2022

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 162 806,40

  • EU contribution

    € 162 806,40

Coordinated by:

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany