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Design of light-harvesting DNA-nanoprobes with ratiometric signal amplification for fluorescence imaging of live cells.

Objective

The project is aimed to develop the novel technique of fluorescent signal amplification upon detection of RNA sequences in living cells up to a single copy level. The novel interdisciplinary approach will be focused on design of innovative fluorescent nanosensors based on polymer nanoparticles (NPs) incorporated with organic dyes, functionalized with DNA shell. The project is predicated on the innovative design of DNA-nanosensors, proposed by the Applicant, which is built on groundbreaking findings of the Host laboratory on ultrabright organic NPs and giant light-harvesting phenomenon that enable strong amplification in detection of nucleic acids. The project relies on contemporary spectroscopy/microscopy facilities and developments of the Host group, and the strong experience of the Applicant in synthesis of fluorescent dyes, design of DNA-probes and bioconjugation techniques.

Call for proposal

H2020-MSCA-IF-2018
See other projects for this call

Coordinator

UNIVERSITE DE STRASBOURG
Address
Rue Blaise Pascal 4
67081 Strasbourg
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 196 707,84