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Design of light-harvesting DNA-nanoprobes with ratiometric signal amplification for fluorescence imaging of live cells.

Project description

Nanoscale RNA sensors for diagnostics

RNA-based methods are gaining momentum in the detection of viruses, the diagnosis of neurodegenerative diseases and tumour profiling. In addition, RNA monitoring is integral to many experimental processes as it impacts cell signalling, gene expression and cell survival. However, analysis requires cell manipulation and RNA extraction, which may cause RNA degradation and lead to erroneous results. The EU-funded DNANanoProbes project has developed DNA nanosensors capable of detecting RNA molecules by imaging. The technology employs fluorescent nanoparticles that hybridise with target RNA molecules. Amplification of signal leads to high sensitivity, which can be exploited for the diagnostic localisation and quantification of RNA in living cells.

Coordinator

UNIVERSITE DE STRASBOURG
Net EU contribution
€ 196 707,84
Address
Rue Blaise Pascal 4
67081 Strasbourg
France

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Region
Grand Est Alsace Bas-Rhin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00