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Unlocking the antibiotic production potential in soil bacteria Streptomyces coelicolor

Project description

Opening the floodgate holding back novel antibiotics could wash away drug resistance

The majority of antibiotics for medical, veterinary and agricultural applications are derived from secondary metabolites produced by the Streptomyces bacteria. However, the huge number of antimicrobial compounds these bacteria currently supply is likely to be only the tip of the iceberg. Much remains unknown about their metabolic pathways. ADP-ribosylation (addition of ADP linked to the sugar ribose) is widely conserved in viruses, bacteria and eukaryotes. It is important in numerous cellular processes and has been linked to antibiotic resistance in bacteria. Following the trail of ADP-ribosylation pathways in Streptomyces, STREPUNLOCKED plans to unlock the potential of these bacteria to deliver novel and effective therapeutics that combat the perfidious and increasing emergence of multi-drug resistant microorganisms.

Call for proposal

H2020-WF-2018-2020

See other projects for this call

Sub call

H2020-WF-01-2018

Coordinator

RUDER BOSKOVIC INSTITUTE
Net EU contribution
€ 147 463,68
Address
Bijenicka Cesta 54
10000 Zagreb
Croatia

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Research Organisations
Other funding
€ 0,00