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Active organotypic models for nanoparticle toxicological screening

Project description

Novel in vitro biomimetic organs will speed nanoparticle testing

The 'eureka' moment is rarely a moment but rather the result of years of strategic experimentation. ActiTOX is developing in vitro biomimetic systems to speed up nanoparticle-based product testing for safety and toxicity while reducing the use of animal experimentation. The team is exploiting human-induced pluripotent stem cells (iPSCs), former adult somatic cells reprogrammed to their embryonic state. Scientists will reprogramme them to differentiate into cells in tissues of interest. The iPSCs will allow ActiTOX to bypass the ethical issues associated with embryonic stem cells while retaining the ability to create biomimetic organs of choice in culture.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells

Call for proposal

H2020-MSCA-RISE-2018
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 161 000

Participants (9)

INOCURE SRO
Czechia
EU contribution
€ 239 200
Address
Politickych Veznu 935/13
11000 Praha
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 124 200
Address
Karlsplatz 13
1040 Wien
Activity type
Higher or Secondary Education Establishments
SZECHENYI ISTVAN UNIVERSITY
Hungary
EU contribution
€ 193 200
Address
Egyetem Ter 1
9026 Gyor
Activity type
Higher or Secondary Education Establishments
OSPIN GMBH
Germany
EU contribution
€ 105 800
Address
Feurigstrasse 54
10827 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAET GRAZ
Austria
EU contribution
€ 69 000
Address
Universitatsplatz 3
8010 Graz
Activity type
Higher or Secondary Education Establishments
BIONEER A/S
Denmark
EU contribution
€ 9 200
Address
Kogle Alle 2
2970 Hoersholm
Activity type
Research Organisations
ORTHOSERA GMBH
Austria
EU contribution
€ 50 600
Address
Dr. Karl-dorrek-strasse 23-29
3500 Krems An Der Donau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE
Czechia
EU contribution
€ 105 800
Address
Videnska 1083
14220 Praha 4
Activity type
Research Organisations
BIOFABICS LDA
Portugal
EU contribution
€ 133 400
Address
Rua Alfredo Allen 455/461
4200-135 Porto
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)