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Microfluidic chambers for establishing physiological and pathological human iPSC-derived neuronal circuits

Project description

Functional brain tissue kits provide a standardised test bench for studying brain circuitry

The human brain has billions of neurons and even more non-neuronal cells that are actually highly organised. The specific interconnections are prerequisite to the myriad functions that make us human – and quite challenging to recreate in cell culture. BrainCircuit-on-chip is changing the rules of the game with a simplified system that achieves patterned and functional connections among several neuronal cell types. Further, the system is easily subjected to pharmacological or other perturbations and dynamic changes can be observed in high-resolution, real-time. In short, it is a major breakthrough for studies of neuronal circuitry and the team is planning to make it available in a frozen toolkit along with instructions to support basic and applied research.

Call for proposal

ERC-2018-PoC
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Host institution

OSPEDALE SAN RAFFAELE SRL
Address
Via Olgettina 60
20132 Milano
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 100 000

Beneficiaries (2)

OSPEDALE SAN RAFFAELE SRL
Italy
EU contribution
€ 100 000
Address
Via Olgettina 60
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
POLITECNICO DI MILANO
Italy
EU contribution
€ 50 000
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Activity type
Higher or Secondary Education Establishments