Does biopsy and surgery induce cancer metastasis?
Cancer diagnosis and treatment often involves biopsy and/or surgical removal of the primary tumour leading to tissue injury. Metastasis, the leading cause of cancer-related deaths, is often initiated by single cells delivered from the primary tumour through the blood stream. This EU-funded project will investigate whether initial tissue injuries significantly contribute to blood-borne dissemination of tumour cells leading to metastasis formation. The research will focus on breast cancer and prostate cancer. It will investigate the impact of the release of circulating cancer cells after biopsy or surgical intervention, and apply novel technologies to capture circulating cells for their functional analysis. Additionally, they will assess therapeutic strategies to prevent the dissemination of viable cancer cells to distant sites.
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