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Impact of tissue injury induced by diagnostic biopsies and surgery on cancer metastasis

Project description

Does biopsy and surgery induce cancer metastasis?

Cancer diagnosis and treatment often involves biopsy and/or surgical removal of the primary tumour leading to tissue injury. Metastasis, the leading cause of cancer-related deaths, is often initiated by single cells delivered from the primary tumour through the blood stream. This EU-funded project will investigate whether initial tissue injuries significantly contribute to blood-borne dissemination of tumour cells leading to metastasis formation. The research will focus on breast cancer and prostate cancer. It will investigate the impact of the release of circulating cancer cells after biopsy or surgical intervention, and apply novel technologies to capture circulating cells for their functional analysis. Additionally, they will assess therapeutic strategies to prevent the dissemination of viable cancer cells to distant sites.

Call for proposal

ERC-2018-ADG
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Host institution

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Address
Martinistrasse 52
20251 Hamburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 499 985

Beneficiaries (1)

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 2 499 985
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments