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Connecting to the Networks of the Human Brain

Objective

ConnectToBrain will introduce whole-brain multi-locus transcranial magnetic stimulation (mTMS), in which the brain-stimulating electric-field location, direction, magnitude and timing are controlled electronically based on real-time high-density electroencephalography (hdEEG) information of activity and connectivity in brain networks. The final mTMS apparatus will consist of 50 coils. Superpositions of electric fields produced by the different overlapping coils allow spatiotemporally millimeter- and millisecond-precise stimulus sequences to arbitrary cortical sites without physical movements of the coil set. Spatial targeting of mTMS will be further improved by measuring individual brain conductivity distributions with ultra-low-field MRI. The proposed hdEEG methodology uses a brain–computer interface (BCI) and a computer–brain interface (CBI) in a closed, algorithmically-controlled loop. BCI receives real-time information about brain activity and connectivity from hdEEG, while CBI adapts mTMS to drive brain activity and connectivity into desired directions. ConnectToBrain will allow unprecedented tracking of dynamic changes and reorganization of brain networks in real-time, and network-targeted closed-loop stimulation. This radically novel technology will cause a paradigm shift from current open-loop practice that is only moderately effective in therapy. We will apply ConnectToBrain to reach new levels of efficacy of therapeutic applications. Patients after stroke and with Alzheimer’s disease will be tested and treated as models of network disorders.
Our high-risk, high-gain endeavor will reach the ambitious goals only through the Synergy of the 3 PIs, world leaders in their complementary areas of expertise (instrumentation, algorithms, translation). If the project succeeds, we expect the value of societal, health and industrial benefits in Europe to exceed €1 billion annually, not to mention the immense value of alleviating human suffering from brain disorders.
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Host institution

AALTO KORKEAKOULUSAATIO SR

Address

Otakaari 1
02150 Espoo

Finland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 998 905

Beneficiaries (3)

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AALTO KORKEAKOULUSAATIO SR

Finland

EU Contribution

€ 3 998 905

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

EU Contribution

€ 2 996 264

UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA

Italy

EU Contribution

€ 2 986 625

Project information

Grant agreement ID: 810377

Status

Ongoing project

  • Start date

    1 September 2019

  • End date

    31 August 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 9 981 794

  • EU contribution

    € 9 981 794

Hosted by:

AALTO KORKEAKOULUSAATIO SR

Finland