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Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis

Objective

Dementia is currently diagnosed largely based on cognitive decline, while pathology starts years before symptom onset. To make progress in the development of effective drugs for dementia, there is an urgent need for biomarkers to enable precision health: for early and specific diagnosis and objective monitoring of disease progression.

With its multidisciplinary team of scientists from academia, industry, and patient organisations, MIRIADE aims to train a new generation of scientists able to optimise and accelerate development of novel biomarkers for dementia.

MIRIADE will integrate biomarker discovery data from multiple platforms and develop a Dementia Disease Map to enhance biomarker identification (WP1). We will develop assays for prioritized biomarkers (WP2), and selected markers will be clinically validated (WP3). We will study pre-analytical stability and validate against regulatory requirements (WP4) and develop a roadmap for optimal biomarker development (WP5). MIRIADE will thus establish an innovative biomarker-focussed cross-sectoral research and training programme that will equip ESRs with a unique combination of skills in big data analysis, biomarker assay development, innovation management, and a thorough understanding of medical needs. This programme will provide a new task force of scientists that are optimally trained to the accelerate the biomarker development for dementias and able to progress effective biomarker tools to the clinic.
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Coordinator

STICHTING VUMC

Address

De Boelelaan 1117
1081 Hv Amsterdam

Netherlands

Activity type

Research Organisations

EU Contribution

€ 265 619,88

Participants (10)

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GOETEBORGS UNIVERSITET

Sweden

EU Contribution

€ 281 982,96

UNIVERSITE DU LUXEMBOURG

Luxembourg

EU Contribution

€ 256 320

UNIVERSITA DEGLI STUDI DI PERUGIA

Italy

EU Contribution

€ 261 499,68

UNIVERSITAET ULM

Germany

EU Contribution

€ 252 788,40

STICHTING VU

Netherlands

EU Contribution

€ 1 062 479,52

CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER

France

EU Contribution

€ 274 802,04

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

EU Contribution

€ 281 982,96

F. HOFFMANN-LA ROCHE AG

Switzerland

EU Contribution

€ 281 276,64

ADX NEUROSCIENCES

Belgium

EU Contribution

€ 512 640

LGC LIMITED

United Kingdom

EU Contribution

€ 303 172,56

Project information

Grant agreement ID: 860197

Status

Ongoing project

  • Start date

    1 November 2019

  • End date

    31 October 2023

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 4 034 564,64

  • EU contribution

    € 4 034 564,64

Coordinated by:

STICHTING VUMC

Netherlands