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The life cycle of extracellular vesicles in prostate cancer: from biogenesis and homing, to functional relevance

Objective

The prostate cancer Extracellular Vesicle LifeCycle (proEVLifeCycle) network is an innovative, multidisciplinary training
program focused on understanding the biology, biomarker potential and function of extracellular vesicles (EVs) to resolve
unmet clinical needs of prostate cancer (PCa). It is within this realm, that we will equip early stage researchers with the
knowledge, tools and a creative ethos to be independent scientists, leaders, and drivers of innovation. The lifecycle of EVs is
poorly understood and their potential as non-invasive biomarkers and therapy target/agents, a growing area of interest. This
research can perfectly be integrated with the high need for novel biomarkers and therapy targets for PCa. Any relief in the
burden of this disease will have major impact on the huge socio-economic problems for patients, families, caregivers and
society.
The ambitious scientific objectives are to unravel the mysteries of EV biogenesis, homing and uptake to explain how vesicles
operate in disease processes; their heterogeneity, their molecular complexity, the biological functions they drive, their local
and systemic dissemination and how these may be manipulated. Using state-of-the-art, network-wide shared model
systems, imaging and profiling tools, and systems biology, the program will enlighten the lifecycle of EVs and identify novel
EV biomarkers and PCa therapy targets to address the unmet clinical needs.
Our original network of 7 academic and 3 company beneficiaries and 11 partners, provides optimal scientific training, crosssectoral
awareness, entrepreneurship skills, communication in the modern age, extensive opportunities for mobility and
patient-facing experiences. We herein meet identified EU-skills gaps providing well-rounded and inventive experts primed for influential careers, contributing to patient well-being and economic prosperity within the EU.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Address

Dr Molewaterplein 40
3015 Gd Rotterdam

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 265 619,88

Participants (9)

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CARDIFF UNIVERSITY

United Kingdom

EU Contribution

€ 303 172,56

TURUN YLIOPISTO

Finland

EU Contribution

€ 280 805,76

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH

Austria

EU Contribution

€ 264 207,24

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS

Spain

EU Contribution

€ 250 904,88

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 274 802,04

FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

Spain

EU Contribution

€ 250 904,88

GenomeScan B.V.

Netherlands

EU Contribution

€ 265 619,88

ANAXOMICS BIOTECH, S.L.

Spain

EU Contribution

€ 250 904,88

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 265 619,88

Project information

Grant agreement ID: 860303

Status

Ongoing project

  • Start date

    1 October 2019

  • End date

    30 September 2023

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 672 561,88

  • EU contribution

    € 2 672 561,88

Coordinated by:

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands