CORDIS
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Heating triggered drug release from nanometric inorganic-metal organic framework composites

Project information

Grant agreement ID: 860942

Status

Grant agreement signed

  • Start date

    1 March 2020

  • End date

    29 February 2024

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 139 408,80

  • EU contribution

    € 3 139 408,80

Coordinated by:

Fundacion IMDEA Energia

Spain

Objective

Although recent advances in nanotechnology have provided an excellent platform to revolutionize the domain of health, the efficient and target delivery of many potent drugs in the body still remains an important challenge due to important drawbacks either from the drug (bioavailability, toxicity, etc.) and/or from the nanocarrier (biocompatibility, reproducibility, insufficient targeting). Consequently, there is currently a real demand for drug nanocarriers able to solve these matters for the different administration routes.
HeatNMof project aims to develop smart multifunctional nanocarriers of challenging antitumoral drugs based on versatile highly porous biocompatible nanometric Metal Organic Frameworks, associated with exceptional drug payloads and controlled releases, and photo- and/or magnetic inorganic nanoparticles, providing both a specific control of reactions inside living entities (i.e. heating-triggered drug release) and additional properties such as imaging (magnetic resonance, thermal or optoacoustic imaging) and/ or hyperthermia therapy.
The successful development of this project, involving academic and industrial partners, will contribute to the improvement of the highly societal relevant cancer therapy. This research objective is strongly related with the prime training/networking aim of HeatNMof: to train the next generation of materials scientists in a highly interdisciplinary and intersectorial research environment, such that they can soundly address upcoming challenges concerning nanomedicine, from the development, optimization and (physicochemical and biological) characterization of inorganic and hybrid materials, as well as their interaction with living entities, with a strong focus on drug delivery platforms based on nanomaterials. HeatNMof will train the next generation of material scientists with sound expertise in nanomedicine, highly needed to bring advanced materials as proposed from the bench to society.

Coordinator

Fundacion IMDEA Energia

Address

Avenida Ramon De La Sagra 3
28935 Mostoles Madrid

Spain

Activity type

Research Organisations

EU Contribution

€ 501 809,76

Participants (9)

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Spain

EU Contribution

€ 250 904,88

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 274 802,04

UNIVERSITEIT ANTWERPEN

Belgium

EU Contribution

€ 256 320

IMMATERIAL LABS LTD

United Kingdom

EU Contribution

€ 303 172,56

INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE INSAT

France

EU Contribution

€ 274 802,04

UNIVERSITAET HAMBURG

Germany

EU Contribution

€ 252 788,40

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italy

EU Contribution

€ 522 999,36

NANOSCALE BIOMAGNETICS SOCIEDAD LIMITADA

Spain

EU Contribution

€ 250 904,88

ISERN PATENTES Y MARCAS M SL

Spain

EU Contribution

€ 250 904,88

Project information

Grant agreement ID: 860942

Status

Grant agreement signed

  • Start date

    1 March 2020

  • End date

    29 February 2024

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 139 408,80

  • EU contribution

    € 3 139 408,80

Coordinated by:

Fundacion IMDEA Energia

Spain