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Studying Ciliary Signaling in Development and Disease

Project description

Characterising regulation of cellular 'hairs' could impact numerous heritable conditions

Eukaryotic cilia are small hair-like organelles. Among the best known are the cilia on epithelial cells lining the airways that move mucous up and out. However, cilia can be motile or non-motile, and are a component of almost all vertebrate cells. Ciliopathies are a rapidly emerging group of human disorders that affect nearly all organ systems. They are associated with inherited mutations, with the number of identified associated genes rising from over 40 genes in 2011 to over 150 by 2017. Prevalent phenotypes include polycystic kidney disease, retinal degeneration, obesity, skeletal malformations and brain anomalies. SCilS is training a new generation of scientists to characterise this increasingly important and diverse class of inherited diseases.

Call for proposal

H2020-MSCA-ITN-2019
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Coordinator

STICHTING RADBOUD UNIVERSITEIT
Address
Houtlaan 4
6525 XZ Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 531 239,76

Participants (9)

KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 892 566
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION
France
EU contribution
€ 549 604,08
Address
24 Bd Du Montparnasse
75015 Paris 15
Activity type
Research Organisations
OSPEDALE SAN RAFFAELE SRL
Italy
EU contribution
€ 261 499,68
Address
Via Olgettina 60
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 297 522
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 252 788,40
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 252 788,40
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
NEWCELLS BIOTECH LIMITED
United Kingdom
EU contribution
€ 303 172,56
Address
1 Times Square Scotswood Road
NE1 4EP Newcastle Upon Tyne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ZECLINICS SL
Spain
EU contribution
€ 250 904,88
Address
Ctra De Can Ruti, Cami De Les Escoles, S/n Laboratori P0-8, Edifici Igtp Muntanya
08916 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CELL NETWORKS GMBH
Germany
EU contribution
€ 252 788,40
Address
Lutherstrasse 59
69120 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)