CORDIS
EU research results

CORDIS

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Mechanism of nucleosome assembly during DNA replication

Project information

Grant agreement ID: 851564

Status

Ongoing project

  • Start date

    1 December 2019

  • End date

    30 November 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Hosted by:

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Netherlands

Project description

English EN

Understanding how post-translational modifications of histones get passed on

Nucleosomes are DNA coiled around histones (proteins). They are the way in which DNA is packaged to fit into the cell's nucleus and, in repeating units, look like beads on a string under a microscope. This complex of DNA and proteins (chromatin) relaxes during transcription to provide transcription factors and other DNA binding proteins access to the DNA. Epigenetic modifications to histone proteins such as methylation can affect gene expression. This, in turn, plays a role in cell fate decisions, tissue development, and immunity. Proper replication of these post-translational modifications along with the DNA prior to cell division is critical, yet mechanisms are largely unknown. EpiRep is studying nucleosome assembly during DNA replication to shed light on this important process.

Host institution

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Address

Kloveniersburgwal 29 Het Trippenhuis
1011 Jv Amsterdam

Netherlands

Activity type

Other

EU Contribution

€ 1 500 000

Beneficiaries (1)

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Netherlands

EU Contribution

€ 1 500 000

Project information

Grant agreement ID: 851564

Status

Ongoing project

  • Start date

    1 December 2019

  • End date

    30 November 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Hosted by:

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Netherlands