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Small-Molecule Drug Conjugates for Targeted Delivery in Tumor Therapy

Objective

"Despite the continuing development of new and more efficient treatments, cancer remains the second cause of premature death worldwide. Multi-faceted interdisciplinary research efforts in industry and academia on different aspects of cancer have provided a knowledge basis for the development of novel therapeutic approaches. Paul Ehrlich, Nobel laureate in Physiology of 1908, had the early vision that a compound could be made to selectively target a disease-causing organism or tumor. A toxin for the particular tissue could be delivered by an agent of selectivity. Such an ideal therapeutic agent would be a ""magic bullet"" that only kills the target cells. This ETN initiative with the title Magicbullet::reloaded refers to Ehrlich’s bold idea and builds on the previous experience of the highly successful ETN MAGICBULLET (2015-2018, grant agreement No. 642004). As a consequence of the outstanding results, the ETN Magicbullet::reloaded will expand the field of investigation from peptide-drug conjugates (PDCs) to small molecule-drug conjugates (SMDCs) with a special focus on drugs capable to stimulate tumor immune responses and overcome resistance to immuno-therapy. The consortium has been substantially expanded to perfectly address the needs of the new research direction. The planned ETN will design and synthesize an array of SMDCs (including PDCs), also targeting less investigated tumor antigens, investigate their pharmacokinetic behaviour, their implication on the immune system, as well as their tumor selectivity and antitumor activity. The consortium brings together interdisciplinary expert knowledge in Organic Chemistry, Peptide Chemistry, Medicinal Chemistry, Drug Discovery, Biochemistry, Pharmacology and Cell Biology. This high complementarity is required for the different scientific tasks in the development pipeline. Vice versa, the recruited ESRs will be exposed to a challenging research environment leading to a broad range of scientific competences to be acquired."

Call for proposal

H2020-MSCA-ITN-2019
See other projects for this call

Coordinator

UNIVERSITAET BIELEFELD
Address
Universitaetsstrasse 25
33615 Bielefeld
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 252 788,40

Participants (14)

EOTVOS LORAND TUDOMANYEGYETEM
Hungary
EU contribution
€ 229 715,28
Address
Egyetem Ter 1-3
1053 Budapest
Activity type
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 281 276,64
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
EXIRIS SRL
Italy
EU contribution
€ 261 499,68
Address
Via Savona Int 2 B 6
00182 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 252 788,40
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
HEIDELBERG PHARMA RESEARCH GMBH
Germany
EU contribution
€ 252 788,40
Address
Gregor Mendel Strasse 22
68526 Ladenburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Orszagos Onkologiai Intezet
Hungary
EU contribution
€ 229 715,28
Address
Rath Gyorgy Utca 7-9.
1122 Budapest
Activity type
Research Organisations
PHILOCHEM AG
Switzerland
EU contribution
€ 281 276,64
Address
Libernstrasse 3
8112 Otelfingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TAKIS SRL
Italy
EU contribution
€ 261 499,68
Address
Via Di Castel Romano 100
00128 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNISCHE UNIVERSITAT DARMSTADT
Germany
EU contribution
€ 252 788,40
Address
Karolinenplatz 5
64289 Darmstadt
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Italy
EU contribution
€ 261 499,68
Address
Via Ravasi 2
21100 Varese
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 261 499,68
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 252 788,40
Address
Albertus Magnus Platz
50931 Koeln
Activity type
Higher or Secondary Education Establishments
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 280 805,76
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 303 172,56
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments