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Global views of cell type specification and differentiation

Project description

Individual cells' fate and destiny during embryogenesis

The fundamental question of developmental biology is how cell lineage (pedigree) and trajectory (history of gene expression) determine its differentiation and specification. Recent progress in gene-editing and sequencing created an opportunity to study the developmental process at single-cell resolution. This EU-funded project is going to employ new methods to reconstruct individual cell fate and evolution during embryogenesis. This global view of cellular development will be generated using zebrafish embryogenesis and organogenesis as a model. Trajectory trees will be established from single-cell RNA sequencing data while lineage trees will be generated using gene-editing for cell marking. Combination of these data will provide the first comprehensive and global view of processes determining vertebrate development.

Field of science

  • /natural sciences/biological sciences/developmental biology
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /humanities/history and archaeology/history

Call for proposal

ERC-2018-ADG
See other projects for this call

Funding Scheme

ERC-ADG - Advanced Grant

Host institution

UNIVERSITAT BASEL
Address
Petersplatz 1
4051 Basel
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 411 440

Beneficiaries (1)

UNIVERSITAT BASEL
Switzerland
EU contribution
€ 2 411 440
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments